HVIDB-PPI detail

P12277 (CKB)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: KCRB_HUMAN

UniProtID: P12277

Gene name(s): CKB;CKBB

Protein name: Creatine kinase B-type

Gene ID: 1152

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P12277-P27958	PHISTO	19264780	electron microscopy

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.009).	Show
Machine learning evidence:	yes (score 0.227).

Combined Score: 0.431

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
5615	Emerin complex 52	23	0.13 (3/23)	17620012	CORUM	View
870	CKM-PPME1-GMCL1-CKB-CRK-HK2	6	0.17 (1/6)	NA	hu.MAP	View
1284	PPME1-CKM-CKB	3	0.33 (1/3)	NA	hu.MAP	View
2911	MYH7B-TPM4-CKB	3	0.33 (1/3)	NA	hu.MAP	View
2963	ASB9-MTHFD2-CKM-PPME1-CKB	5	0.20 (1/5)	NA	hu.MAP	View
4558	MTHFD2-CKM-CKB	3	0.33 (1/3)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE15810	hMSCs_mock-transduced	hMSCs_BV-transduced	up	2.71	6.53e-04	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	2.40	4.83e-03	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-2.49	7.17e-03	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-2.24	8.04e-05	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-2.34	1.31e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_DeltaE_7hpi	down	-1.54	4.92e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_WT_7hpi	down	-1.65	1.87e-05	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	5.04	9.26e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	1.53	1.91e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	1.76	3.23e-03	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-2.43	3.55e-05	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	up	1.53	8.45e-04	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.88	5.37e-06	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.65	1.09e-03	Microarray data
GSE64605	HS_unifected	HS_Q70_or_M91_infected	up	2.18	5.34e-06	Microarray data
GSE64605	HS_unifected	HS_R70_or_L91_infected	up	1.78	7.68e-06	Microarray data
GSE65574	MCL001_mock_0h	MCL001_d3-5-MERS_0h	down	-1.94	4.69e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-2.29	1.21e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-3.62	1.74e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-4.14	2.52e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_dNSP16-MERS_12h	down	-1.92	8.70e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-3.27	1.16e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-1.79	8.09e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-2.53	4.17e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.26	3.03e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	2.04	2.98e-04	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-3.02	1.88e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.16	9.38e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	up	3.63	1.66e-08	RNA-Seq data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.87	9.01e-03	Microarray data
GSE99389	CD4+_mock_infected_4d	LPS_infected_4d	up	2.00	6.53e-03	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	2.63	3.35e-04	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	3.00	5.97e-04	Microarray data
GSE68503	empty_vector_control	tumor-derived_LT339	up	1.95	2.45e-02	Microarray data
GSE68503	empty_vector_control	tumor-derived_LT339+sT	up	2.12	7.19e-03	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	down	-1.57	1.06e-06	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	2.52	8.60e-10	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	3.77	1.41e-27	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	2.25	5.43e-07	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	1.96	4.10e-07	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	2.75	1.25e-11	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	3.57	3.05e-19	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	2.17	8.68e-04	RNA-Seq data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	2.56	3.68e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	3.97	3.09e-04	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000166165
Gene description:	Creatine kinase B
Chromosome:	14
Position	103519659-103523111
Protein class:	Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol