HVIDB-PPI detail

P11137 (MAP2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: MTAP2_HUMAN

UniProtID: P11137

Gene name(s): MAP2

Protein name: Microtubule-associated protein 2

Gene ID: 4133

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P11137-P27958	PHISTO	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.025).	Show
Machine learning evidence:	yes (score 0.138).

Combined Score: 0.258

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2659	Calcineurin	10	0.10 (1/10)	NA	hu.MAP	View
2868	SNARE complex (VAMP2, SNAP25, STX1a, CPLX2)	60	0.05 (3/60)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	2.78	1.90e-02	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	2.67	3.56e-02	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_8h	up	1.88	3.94e-08	RNA-Seq data
GSE19345	Mock_infected	HCMV_infected_24h	down	-2.12	4.40e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.60	1.45e-02	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.97	1.24e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	1.90	5.85e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	1.71	6.86e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-6.67	2.74e-06	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	down	-3.89	3.22e-05	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-2.01	5.05e-03	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	up	2.15	7.27e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	1.93	1.77e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	2.21	1.23e-06	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	down	-1.58	1.31e-02	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	1.52	1.15e-10	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	2.14	5.11e-08	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	6.45	3.77e-02	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	3.04	1.25e-19	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	2.55	5.30e-13	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	3.16	1.71e-04	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	8.53	6.22e-06	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	3.32	2.51e-02	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	2.42	3.43e-02	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	1.74	4.28e-02	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_24h	up	1.59	1.01e-06	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	1.52	5.92e-04	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enriched:

Tissue	Expression (TPM)
cerebral cortex	296.5

Ensembl ID:	ENSG00000078018
Gene description:	Microtubule associated protein 2
Chromosome:	2
Position	209424058-209734118
Protein class:	FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoli, Cytosol