HVIDB-PPI detail

P11021 (HSPA5)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: BIP_HUMAN

UniProtID: P11021

Gene name(s): HSPA5;GRP78

Protein name: Endoplasmic reticulum chaperone BiP

Gene ID: 3309

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P11021-P27958	PHISTO,biogrid,HPIDB,VirusMentha	22810585	affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.357).

Combined Score: 0.994

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1223	H2AX complex, isolated from cells without IR exposure	13	0.38 (5/13)	16522924	CORUM	View
1226	H2AX complex I	7	0.29 (2/7)	16522924	CORUM	View
1227	H2AX complex II	10	0.30 (3/10)	16522924	CORUM	View
1335	SNW1 complex	18	0.17 (3/18)	12840015	CORUM	View
2721	HCF-1 complex	18	0.17 (3/18)	12670868	CORUM	View
3082	DGCR8 multiprotein complex	11	0.36 (4/11)	17765891	CORUM	View
6859	HRD1 complex	13	0.08 (1/13)	28411238	CORUM	View
929	CEN complex	37	0.08 (3/37)	15009096	CORUM	View
309	ANO3-HSPA5	2	0.50 (1/2)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE100839	mock_infected	EBOV_infected	up	2.34	3.56e-63	RNA-Seq data
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	1.59	3.26e-10	RNA-Seq data
GSE69602	cytosol_unifected	cytosol_DENV2_infected_24h	up	7.04	1.16e-02	RNA-Seq data
GSE69602	cytosol_unifected	cytosol_DENV2_infected_40h	up	7.52	5.53e-03	RNA-Seq data
GSE84285	A549_mock_infected_24h	A549_Dengue_virus_infected_24h	up	2.34	5.20e-304	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	up	2.10	7.79e-248	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-3.53	1.89e-03	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	1.53	7.99e-04	Microarray data
GSE31518	A549_mock_infection	A549_pH1N1_infection_10h	up	1.51	7.79e-06	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	1.71	5.94e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	2.71	4.05e-05	Microarray data
GSE35473	MOI_uninfected	MOI_influenza_A_infected	up	3.88	3.79e-02	Microarray data
GSE47937	mock_infected	A_WSN_33_infected	up	2.67	2.09e-09	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	up	2.50	2.51e-09	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group2	up	2.53	1.74e-09	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	2.32	6.93e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	1.73	1.34e-06	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-2.49	1.14e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-1.89	7.35e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-1.71	3.06e-02	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	1.72	6.17e-11	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.33	5.07e-38	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.14	2.76e-35	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-2.30	1.20e-54	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-1.82	2.07e-32	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-1.80	2.13e-26	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.38	4.55e-24	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-1.90	3.16e-24	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.13	2.90e-33	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_24h	up	1.54	1.24e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	1.54	5.96e-04	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000044574
Gene description:	Heat shock protein family A (Hsp70) member 5
Chromosome:	9
Position	125234853-125241330
Protein class:	Disease related genes, Plasma proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol