HVIDB-PPI detail

Homo sapiens

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Human protein: CH60_HUMAN

UniProtID: P10809

Gene name(s): HSPD1;HSP60

Protein name: 60 kDa heat shock protein

Gene ID: 3329

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P10809-P27958-PRO_0000037566	HPIDB	15846844	pull down

Evidence suggesting a protein interaction:

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1094	Frataxin complex	7	0.14 (1/7)	17331979	CORUM	View
2755	17S U2 snRNP	33	0.09 (3/33)	12234937	CORUM	View
611	RCN1-BTF3-NACA2-HSPD1-CALU-DLST	6	0.33 (2/6)	NA	hu.MAP	View
1083	HSPD1-LRRC28	2	0.50 (1/2)	NA	hu.MAP	View
3412	DBC1-SIRT1 complex	2	0.50 (1/2)	NA	hu.MAP	View
4519	HSPD1-ATP5A1-NACA2-BTF3-CALU-DLST	6	0.33 (2/6)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-1.80	4.87e-11	RNA-Seq data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-1.59	5.59e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-1.89	1.72e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.92	1.69e-06	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Ensembl ID:	ENSG00000144381
Gene description:	Heat shock protein family D (Hsp60) member 1
Chromosome:	2
Position	197486581-197516737
Protein class:	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Mitochondria