Human protein: THIO_HUMAN
UniProtID: P10599
Gene name(s): TXN;TRDX;TRX;TRX1
Protein name: Thioredoxin
Gene ID: 7295
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P10599-P27958 | PHISTO,biogrid,HPIDB,VirusMentha | 22810585 | affinity chromatography technology,tandem affinity purification |
| Interolog evidence: | yes (score 0.696). | Show |
| DDI evidence: | none/insignificant. | |
| Machine learning evidence: | yes (score 0.083). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 2250 | GLOD4-TXN | 2 | 0.50 (1/2) | NA | hu.MAP | View |
| 2757 | TXN-TXN2 | 2 | 0.50 (1/2) | NA | hu.MAP | View |
| 3210 | AIP-DPY30-TXN-TXN2 | 4 | 0.25 (1/4) | NA | hu.MAP | View |
| 3648 | RGN-SOD1-GLOD4-TXN-TXN2 | 5 | 0.20 (1/5) | NA | hu.MAP | View |
| 3748 | RUNX1-CBF-beta-DNA complex | 8 | 0.12 (1/8) | NA | hu.MAP | View |
| 4279 | RGN-SOD1-TXN-TXN2-TANGO2 | 5 | 0.20 (1/5) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE69602 | cytosol_unifected | cytosol_DENV2_infected_24h | up | 7.92 | 1.67e-03 | RNA-Seq data |
| GSE69602 | cytosol_unifected | cytosol_DENV2_infected_6h | up | 8.00 | 2.26e-02 | RNA-Seq data |
| GSE30589 | Vero_E6_Mock_infected_15hpi | Vero_E6_SARS-Cov_DeltaE_15hpi | down | -2.66 | 1.34e-06 | Microarray data |
| GSE30589 | Vero_E6_Mock_infected_15hpi | Vero_E6_SARS-Cov_WT_15hpi | down | -2.70 | 8.99e-07 | Microarray data |
| GSE49628 | Bcells_Quiescent | Bcells_Activation | up | 1.58 | 6.70e-04 | Microarray data |
| GSE49628 | Bcells_Quiescent | Bcells_EBV_transformed | up | 2.12 | 2.51e-04 | Microarray data |
| GSE93861 | healthy_blood_control | Ebola_infection | up | 1.99 | 1.32e-14 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000136810 |
| Gene description: | Thioredoxin |
| Chromosome: | 9 |
| Position | 110243811-110256640 |
| Protein class: | Plasma proteins, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleus, Nucleoli, Cytosol |