HVIDB-PPI detail

P0DMV8 (HSPA1A)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: HS71A_HUMAN

UniProtID: P0DMV8

Gene name(s): HSPA1A;HSP72;HSPA1;HSX70

Protein name: Heat shock 70 kDa protein 1A

Gene ID: 3303;3304

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P0DMV8-P27958	PHISTO	17616579	Other Methods

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.439).

Combined Score: 0.999

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
115	Polycomb repressive complex 1 (PRC1, hPRC-H)	12	0.08 (1/12)	12167701	CORUM	View
116	Polycomb repressive complex 1 (PRC1, hPRC-H)	13	0.15 (2/13)	12167701	CORUM	View
432	N-NOS-CHIP-HSP70-1 complex	3	0.33 (1/3)	15466472	CORUM	View
5423	HSP70-BAG5-PARK2 complex	4	0.50 (2/4)	15603737	CORUM	View
6115	BAG1-HSP70 complex	2	0.50 (1/2)	9305631	CORUM	View
626	LSD1 complex	14	0.07 (1/14)	16140033	CORUM	View
725	P2X7 receptor signalling complex	12	0.25 (3/12)	11707406	CORUM	View
7269	p532-Clathrin-HSP70 complex	3	0.33 (1/3)	9233772	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE100839	mock_infected	EBOV_infected	up	2.50	1.79e-78	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-2.48	2.22e-03	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	2.43	1.30e-09	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	1.84	2.38e-07	RNA-Seq data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	2.40	5.49e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	2.40	5.49e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	1.99	7.23e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	1.99	7.23e-05	Microarray data
GSE19345	Mock_infected	HCMV_infected_12h	up	2.13	1.88e-04	Microarray data
GSE19345	Mock_infected	HCMV_infected_12h	up	2.13	1.88e-04	Microarray data
GSE20948	Huh7_mock_infected_12h	Huh7_JFH-1_infected_12h	down	-2.45	6.22e-07	Microarray data
GSE20948	Huh7_mock_infected_12h	Huh7_JFH-1_infected_12h	down	-2.45	6.22e-07	Microarray data
GSE20948	Huh7_mock_infected_24h	Huh7_JFH-1_infected_24h	down	-1.52	2.48e-06	Microarray data
GSE20948	Huh7_mock_infected_24h	Huh7_JFH-1_infected_24h	down	-1.52	2.48e-06	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-2.18	3.68e-03	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-2.18	3.68e-03	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-2.56	2.17e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.50	6.14e-03	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_DeltaE_24h	up	3.22	3.43e-07	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_DeltaE_24h	up	3.22	3.43e-07	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_DeltaE_65h	up	4.84	1.23e-06	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_DeltaE_65h	up	4.84	1.23e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	up	2.90	2.38e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	up	2.90	2.38e-07	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_6h	up	1.59	2.25e-06	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_6h	up	1.59	2.25e-06	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.54	4.25e-03	Microarray data
GSE47937	mock_infected	A_WSN_33_infected	down	-1.64	8.55e-08	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-1.94	1.73e-07	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-2.11	5.82e-08	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group2	down	-1.65	4.15e-07	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group2	down	-1.73	4.29e-07	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	up	2.32	8.98e-08	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	up	2.32	8.98e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Anhui01_pCalu3_12h	down	-1.88	8.80e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_NL219_pCalu3_12h	down	-1.51	1.72e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_NL219_pCalu3_12h	down	-2.07	1.80e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	down	-1.82	7.41e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-2.24	4.50e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_7h	Hu_NL219_pCalu3_7h	down	-1.84	5.84e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_7h	Hu_NL219_pCalu3_7h	down	-1.63	4.82e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_7h	Hu_Pan99_pCalu3_7h	down	-1.62	4.45e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_7h	Hu_Pan99_pCalu3_7h	down	-1.70	6.61e-03	Microarray data
GSE57647	Mock_infection_48h	JEV_infection_48h	up	1.63	1.11e-04	Microarray data
GSE57647	Mock_infection_48h	JEV_infection_48h	up	1.54	7.99e-05	Microarray data
GSE58605	A549_mock_infection_24h	A549_VA-_virus_infection_24h	down	-2.26	9.68e-04	Microarray data
GSE58605	A549_mock_infection_24h	A549_VA-_virus_infection_24h	down	-2.26	9.68e-04	Microarray data
GSE58605	A549_mock_infection_24h	A549_VA+_virus_infection_24h	down	-1.73	2.81e-02	Microarray data
GSE58605	A549_mock_infection_24h	A549_VA+_virus_infection_24h	down	-1.73	2.81e-02	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-1.53	7.63e-06	RNA-Seq data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.47	1.40e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-1.50	6.77e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.52	1.89e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-1.60	1.49e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.72	1.87e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.96	3.52e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-1.58	9.76e-04	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	1.76	2.92e-02	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-1.75	1.47e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.39	7.13e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-1.51	1.11e-02	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_3h	HTBE_H1N1_MOI5_infected_3h	up	2.77	7.17e-16	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	2.31	2.13e-03	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	2.82	6.16e-04	Microarray data
GSE87750-GPL16791	hPN_mock_infected	hPN_ZIKV-PRVABC59_infected	up	1.94	3.27e-02	RNA-Seq data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	1.86	2.55e-12	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	1.81	8.57e-12	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_InfluenzaVirus_48hrs	up	1.67	1.07e-10	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_InfluenzaVirus_48hrs	up	1.62	2.44e-10	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	2.40	5.11e-05	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	3.98	1.31e-89	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	1.55	5.19e-10	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_60hrs	down	-1.81	1.46e-12	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_60hrs	down	-1.97	4.35e-14	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrs	down	-2.21	1.13e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrs	down	-2.37	1.16e-14	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	2.39	2.62e-30	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_60hrs	down	-1.89	1.30e-12	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_60hrs	down	-2.05	5.77e-14	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	3.49	1.31e-09	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_72hrs	down	-2.24	4.33e-14	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_72hrs	down	-2.38	2.04e-15	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	3.91	3.36e-161	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_60hrs	down	-2.27	1.36e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_60hrs	down	-2.38	8.08e-15	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	down	-2.31	4.82e-14	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	down	-2.44	2.18e-15	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	5.17	1.61e-03	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	2.57	2.93e-44	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	2.45	4.43e-02	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	2.67	3.11e-51	RNA-Seq data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	1.59	2.24e-03	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	1.52	4.78e-08	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000204389
Gene description:	Heat shock protein family A (Hsp70) member 1A
Chromosome:	6
Position	31815464-31817946
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm, Vesicles