HVIDB-PPI detail

P0C0S8 (H2AC11)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: H2A1_HUMAN

UniProtID: P0C0S8

Gene name(s): H2AC11;H2AFP;HIST1H2AG;;H2AC13;H2AFC;HIST1H2AI;;H2AC15;H2AFD;HIST1H2AK;;H2AC16;H2AFI;HIST1H2AL;;H2AC17;H2AFN;HIST1H2AM

Protein name: Histone H2A type 1

Gene ID: 8329;8330;8332;8336;8969

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P0C0S8-P27958	biogrid,HPIDB	22810585	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.081).	Show
Machine learning evidence:	yes (score 0.135).

Combined Score: 0.999

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
4296	HIST1H2AG-HIST1H4A	2	1.00 (2/2)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE28166	mock_infected_18h	VN1203_infected_18h	up	2.75	2.58e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	3.48	2.00e-05	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.60	5.37e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	1.99	1.78e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.75	1.60e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	2.37	8.36e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-1.96	3.00e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-2.41	4.62e-05	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	up	1.51	4.30e-04	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	up	1.86	4.11e-04	Microarray data
GSE36854	NK_uninfected	IHD-W_infected	up	5.88	3.05e-02	Microarray data
GSE36854	NK_uninfected	IHD-W_infected	up	4.80	3.90e-02	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-1.57	1.37e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.54	1.09e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.73	2.56e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	down	-2.17	8.12e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.97	5.49e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.62	4.20e-06	Microarray data
GSE53103	Namalwa_shscr	Namalwa_shscr_+SV_6h	down	-1.53	2.76e-05	Microarray data
GSE65123	healthy_seronegative_control	HCV_infected	up	2.18	3.24e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_d3-5-MERS_0h	down	-2.03	3.77e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-1.90	7.04e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-3.74	2.96e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.52	1.26e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-3.12	2.18e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_dNSP16-MERS_12h	down	-1.61	4.42e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-1.65	4.26e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.58	2.27e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-1.89	5.34e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.40	3.96e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-1.89	7.89e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.56	6.28e-03	Microarray data
GSE93861	healthy_blood_control	Ebola_infection	up	2.64	1.80e-19	Microarray data
GSE93861	healthy_blood_control	Ebola_infection	up	3.13	3.12e-17	Microarray data

Human tissue specific expression (TPM)