HVIDB-PPI detail

P09758 (TACSTD2)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: TACD2_HUMAN

UniProtID: P09758

Gene name(s): TACSTD2;GA733-1;M1S1;TROP2

Protein name: Tumor-associated calcium signal transducer 2

Gene ID: 4070

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P09758-P27958-PRO_0000037576	HPIDB	15607035	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.649).

Combined Score: 1.000

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84346	uninfected_control	HCV_infected_high_ISG	up	1.52	4.13e-02	RNA-Seq data
GSE84346	uninfected_control	HCV_infected_low_ISG	up	2.16	5.74e-03	RNA-Seq data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.52	3.58e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-2.41	4.62e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.83	2.72e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	15.86	1.11e-07	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	14.86	3.13e-07	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	15.83	1.43e-07	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	14.84	2.99e-07	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-2.36	6.07e-05	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	3.68	1.69e-04	Microarray data
GSE53543	uninfected_control	RV_infected	down	-2.09	8.24e-25	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	up	7.11	7.37e-04	RNA-Seq data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-3.80	1.60e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-3.31	7.07e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-3.22	1.41e-02	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-3.90	4.14e-04	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.90	1.48e-31	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-3.31	1.53e-58	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	down	-1.68	1.03e-07	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-1.96	4.62e-07	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-3.06	1.77e-04	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-1.73	4.66e-08	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.52	3.36e-30	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-2.21	5.00e-19	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.39	2.22e-16	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.99	4.83e-15	RNA-Seq data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	down	-2.31	1.38e-03	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
esophagus	313.8

Ensembl ID:	ENSG00000184292
Gene description:	Tumor-associated calcium signal transducer 2
Chromosome:	1
Position	58575423-58577773
Protein class:	Disease related genes, Predicted membrane proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoli, Vesicles, Plasma membrane