HVIDB-PPI detail

P08727 (KRT19)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: K1C19_HUMAN

UniProtID: P08727

Gene name(s): KRT19

Protein name: Keratin

Gene ID: 3880

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P08727-P27958	PHISTO	15846844	pull down

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.631).	Show
DDI evidence:	yes (score 0.002).	Show
Machine learning evidence:	yes (score 0.165).

Combined Score: 0.849

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE1377	uninfected_control	KSHV_infected	down	-5.17	3.33e-02	Microarray data
GSE15520	Naive_Huh7	Norwalk_virus_HG23	down	-2.26	1.16e-05	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-2.21	8.25e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-3.16	1.43e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-3.52	2.09e-05	Microarray data
GSE38941	nomal_liver	HBV-associated_acute_liver_failure_liver	up	2.78	6.24e-13	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.55	5.56e-05	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-3.40	5.17e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-2.47	2.78e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-2.87	4.75e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-3.46	8.28e-08	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.01	1.87e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.73	2.12e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.19	7.39e-05	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-2.03	4.36e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-2.21	3.99e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-1.78	1.98e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-2.03	1.09e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.28	4.27e-02	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-3.40	1.78e-48	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-4.63	2.54e-167	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	down	-1.68	3.28e-14	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-2.87	5.19e-03	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	5.38	1.42e-05	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	1.63	7.99e-04	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000171345
Gene description:	Keratin 19
Chromosome:	17
Position	41523617-41528308
Protein class:	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Intermediate filaments