HVIDB-PPI detail

P08670 (VIM)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: VIME_HUMAN

UniProtID: P08670

Gene name(s): VIM

Protein name: Vimentin

Gene ID: 7431

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P08670-P27958-PRO_0000037566	HPIDB	15846844	anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.997).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.828).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
6509	pERK-vimentin-KPNA2 complex	3	0.33 (1/3)	25728791	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84897	MKN7_WT_control	MKN7_EBV_infected	down	-5.44	1.46e-09	RNA-Seq data
GSE19345	Mock_infected	HCMV_infected_24h	down	-1.50	9.35e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.72	7.07e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.97	2.97e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-15.76	8.82e-08	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-2.42	3.54e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-13.93	1.17e-07	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-4.24	3.14e-03	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-1.50	1.00e-06	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-1.83	6.72e-05	Microarray data
GSE59226	Control	Virus_infection	down	-1.77	2.02e-04	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-1.69	4.22e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.99	3.40e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-1.62	1.13e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.20	3.10e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.68	2.38e-03	Microarray data
GSE67198	uninfected_control	150HA_u_per_mL_Sev_infected	up	2.12	8.28e-05	Microarray data
GSE99298	mock_infected_0h	hRSV_NS1_Y125A_infected_96h	up	2.63	2.50e-10	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.28	3.23e-32	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-1.51	5.03e-21	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-1.67	4.23e-28	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-1.60	2.24e-19	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000026025
Gene description:	Vimentin
Chromosome:	10
Position	17228259-17237593
Protein class:	Disease related genes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Intermediate filaments