Human protein: HCK_HUMAN
UniProtID: P08631
Gene name(s): HCK
Protein name: Tyrosine-protein kinase HCK
Gene ID: 3055
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P08631-P27958 | PHISTO,HPIDB,IntAct,VirusMentha | 15784897,14993658 | pull down,anti bait coimmunoprecipitation |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE27702 | control_macrophages | FPV-infected_macrophages | down | -2.12 | 1.20e-02 | Microarray data |
| GSE32155 | CRL-5800_unifected | CRL-1472_infected | down | -4.23 | 1.99e-04 | Microarray data |
| GSE32155 | CRL-5800_unifected | CRL-5807_infected | down | -4.86 | 4.56e-05 | Microarray data |
| GSE38941 | nomal_liver | HBV-associated_acute_liver_failure_liver | up | 2.50 | 1.29e-10 | Microarray data |
| GSE49628 | Bcells_Quiescent | Bcells_EBV_transformed | down | -2.76 | 3.78e-04 | Microarray data |
| GSE53103 | Namalwa_shscr | Namalwa_shscr_+SV_6h | down | -1.69 | 4.22e-06 | Microarray data |
| GSE99389 | CD4+_mock_infected_4d | EBOV_infected_4d | down | -1.58 | 2.16e-02 | RNA-Seq data |
| GSE67198 | uninfected_control | 150HA_u_per_mL_Sev_infected | up | 1.64 | 9.64e-06 | Microarray data |
| GSE89008 | HTBE_H1N1_MOI0_mock_infected_24h | HTBE_H1N1_MOI5_infected_24h | down | -3.24 | 3.98e-02 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-520_H5N1_MOI0_18h | MDM-520_H5N1_MOI2_18h | down | -1.62 | 2.89e-22 | RNA-Seq data |
| GSE97672-GPL18573 | MDM-513_H5N1_MOI0_18h | MDM-513_H5N1_MOI2_18h | down | -1.82 | 3.91e-42 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Tissue enhanced:
| Tissue | Expression (TPM) |
|---|---|
| appendix | 149.6 |
| spleen | 113.2 |
| Ensembl ID: | ENSG00000101336 |
| Gene description: | HCK proto-oncogene, Src family tyrosine kinase |
| Chromosome: | 20 |
| Position | 32052188-32101856 |
| Protein class: | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleoplasm, Plasma membrane |