HVIDB-PPI detail

P08493 (MGP)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: MGP_HUMAN

UniProtID: P08493

Gene name(s): MGP;MGLAP;GIG36

Protein name: Matrix Gla protein

Gene ID: 4256

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P08493-P27958	PHISTO	15607035	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.058).

Combined Score: 0.031

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	5.86	3.74e-03	RNA-Seq data
GSE84897	MKN7_WT_control	MKN7_EBV_infected	down	-5.85	1.48e-05	RNA-Seq data
GSE13637	HUVEC_control	FPV-infected_pEGZ-transfected_HUVEC	up	1.67	2.20e-06	Microarray data
GSE13637	HUVEC_control	H5N1-infected_IKK2kd-transfected_HUVEC	up	1.56	5.22e-05	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	up	1.81	6.77e-03	Microarray data
GSE27702	control_macrophages	H5N1-infected_macrophages	up	2.04	2.73e-02	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.82	4.93e-03	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-2.18	2.54e-02	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	3.42	3.65e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	3.93	1.98e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	3.36	3.58e-02	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	3.87	1.22e-02	Microarray data
GSE38941	nomal_liver	HBV-associated_acute_liver_failure_liver	up	1.69	8.52e-07	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	down	-3.94	6.08e-03	Microarray data
GSE68503	empty_vector_control	tumor-derived_LT339+sT	down	-7.50	2.50e-02	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	7.16	2.41e-02	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	4.76	3.55e-02	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	8.39	3.20e-05	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	5.14	1.36e-03	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	8.13	2.51e-02	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	6.53	2.76e-02	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
breast	4883.1

Ensembl ID:	ENSG00000111341
Gene description:	Matrix Gla protein
Chromosome:	12
Position	14881181-14885926
Protein class:	Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location: