HVIDB-PPI detail

Homo sapiens

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Human protein: HS90B_HUMAN

UniProtID: P08238

Gene name(s): HSP90AB1;HSP90B;HSPC2;HSPCB

Protein name: Heat shock protein HSP 90-beta

Gene ID: 3326

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P08238-P27958	PHISTO	19150985	anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Combined Score: 0.995

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2112	CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex	4	0.50 (2/4)	15001580	CORUM	View
3032	RNA-induced silencing complex, RISC	4	0.50 (2/4)	16357216	CORUM	View
5199	Kinase maturation complex 1	16	0.19 (3/16)	14743216	CORUM	View
5212	Kinase maturation complex 2	8	0.50 (4/8)	14743216	CORUM	View
5234	IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex	5	0.60 (3/5)	14743216	CORUM	View
5266	TNF-alpha/NF-kappa B signaling complex 6	14	0.36 (5/14)	14743216	CORUM	View
5268	TNF-alpha/NF-kappa B signaling complex 7	8	0.25 (2/8)	14743216	CORUM	View
5269	TNF-alpha/NF-kappa B signaling complex 8	6	0.50 (3/6)	14743216	CORUM	View
5285	TNF-alpha/NF-kappa B signaling complex 9	5	0.20 (1/5)	14743216	CORUM	View
5286	TNF-alpha/NF-kappa B signaling complex 10	10	0.30 (3/10)	14743216	CORUM	View
5849	HSP90-CDC37-LRRK2 complex	3	0.33 (1/3)	16321986	CORUM	View
5980	LRRK2-CHIP-HSP90 complex	3	0.33 (1/3)	19196961	CORUM	View
6190	p38gamma-Hsp90-K-Ras complex	3	0.33 (1/3)	24962213	CORUM	View
6706	CAPN1-HSP90AB1 complex	2	0.50 (1/2)	25575026	CORUM	View
725	P2X7 receptor signalling complex	12	0.25 (3/12)	11707406	CORUM	View
1056	Kinase maturation complex 1	4	0.50 (2/4)	NA	hu.MAP	View
2146	Ribosome, cytoplasmic	143	0.13 (18/143)	NA	hu.MAP	View
2985	Ribosome, cytoplasmic	139	0.12 (16/139)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-1.85	1.05e-17	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-1.92	3.48e-15	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-2.90	1.46e-03	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-3.22	4.19e-07	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-1.61	7.30e-05	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	3.63	4.06e-03	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-3.60	1.05e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-3.62	1.14e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-3.10	1.27e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-3.41	1.85e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_icMERS_7h	down	-2.06	2.30e-02	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.67	1.52e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_6h	HTBE_H5N1_MOI5_infected_6h	down	-1.51	1.71e-18	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.99	6.47e-33	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.27	5.97e-76	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-1.55	3.63e-31	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Ensembl ID:	ENSG00000096384
Gene description:	Heat shock protein 90 alpha family class B member 1
Chromosome:	6
Position	44246166-44253888
Protein class:	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol