P07948 (LYN)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: LYN_HUMAN

UniProtID: P07948

Gene name(s): LYN;JTK8

Protein name: Tyrosine-protein kinase Lyn

Gene ID: 4067

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P07948-P27958PHISTO,HPIDB,IntAct,VirusMentha15784897,14993658pull down,anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 1.000). Show
DDI evidence: yes (score 0.045). Show
Machine learning evidence: yes (score 0.291).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2536PLC-gamma-2-SLP-76-Lyn-Grb2 complex40.50 (2/4)10469124CORUMView
2563FGFR2-c-Cbl-Lyn-Fyn complex40.50 (2/4)15190072CORUMView
2564p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated40.50 (2/4)1544885CORUMView
2565CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line)40.75 (3/4)7545683CORUMView
2910PLC-gamma-2-Lyn-FcR-gamma complex30.33 (1/3)10469124CORUMView
461p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated80.12 (1/8)NAhu.MAPView
662p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated60.17 (1/6)NAhu.MAPView
667p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated170.12 (2/17)NAhu.MAPView
1500p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated140.21 (3/14)NAhu.MAPView
2860p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated30.33 (1/3)NAhu.MAPView
3172p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated40.25 (1/4)NAhu.MAPView
4235p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated60.33 (2/6)NAhu.MAPView
4236p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated40.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE61141non-asthmatic_Vehiclenon-asthmatic_HRV16up1.692.46e-07RNA-Seq data
GSE75699HNBE_control_0hHNBE_infected_24hup1.922.51e-06RNA-Seq data
GSE19345Mock_infectedHCMV_infected_24hup1.672.31e-04Microarray data
GSE32155CRL-5800_unifectedCRL-1472_infectedup3.367.05e-05Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infectedup3.887.30e-05Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup4.185.58e-06Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infectedup4.709.52e-06Microarray data
GSE32155HTB-4_unifectedHTB-174_infectedup3.042.20e-05Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infecteddown-2.127.75e-04Microarray data
GSE49628Bcells_QuiescentBcells_Activationdown-1.612.82e-04Microarray data
GSE50938polysomal_RNA_mock-infected_NHDFspolysomal_RNA_HCMV-infected_HNDFs_48h_post-infectionup1.755.84e-03Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-1.681.63e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-2.443.09e-05Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.569.93e-03Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup1.717.85e-03Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-2.158.55e-04Microarray data
GSE89008HTBE_H3N2_MOI0_mock_infected_18hHTBE_H3N2_MOI5_infected_18hup1.554.07e-09RNA-Seq data
GSE99858PBMC_controlPBMC_RV16_infectionup1.526.87e-08Microarray data

Human tissue specific expression (TPM)

Small intestine: 41.8 Liver: 11.4 Gallbladder: 53.9 Duodenum: 45.3 Rectum: 20.6 Tonsil: 69.5 Stomach: 15.1 Salivary glanda: 4.4 Adipose tissue: 28.7 Lung: 54.6 Lymph node: 83.5 Pancreas: 2.4 Kidney: 8.8 Colon: 17.1 Appendix: 130.6 Smooth musle: 27.6 Breast: 14.0 Parathyroid gland: 14.3 Esophagus: 12.9 Heart muscle: 4.7 Spleen: 161.1 Skeletal muscle: 0.8 Bone marrow: 69.6 Skin: 5.2 Urinary bladder: 36.5 Cervix, uterine: 21.9 Endometrium: 13.9 Ovary: 5.8 Fallopian tube: 22.2 Seminal vesicle: 17.9 Prostate: 11.9 Epididymis: 8.8 Testis: 7.9 Placenta: 46.5 Thyroid gland: 23.0 Cerebral cortex: 13.8 Adrenal gland: 14.2
Expression value is measured by Transcripts Per Million (TPM)
Tissue enhanced:
TissueExpression (TPM)
spleen 161.1
Ensembl ID:ENSG00000254087
Gene description:LYN proto-oncogene, Src family tyrosine kinase
Chromosome:8
Position55879813-56014168
Protein class:Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Golgi apparatus, Vesicles, Plasma membrane