P07900 (HSP90AA1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: HS90A_HUMAN

UniProtID: P07900

Gene name(s): HSP90AA1;HSP90A;HSPC1;HSPCA

Protein name: Heat shock protein HSP 90-alpha

Gene ID: 3320

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P07900-P27958PHISTO19150985anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.008). Show
Machine learning evidence: yes (score 0.329).
Combined Score: 0.994


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2112CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex40.50 (2/4)15001580CORUMView
2721HCF-1 complex180.17 (3/18)12670868CORUMView
4158HSP90-FKBP38-CAM-Ca(2+) complex30.67 (2/3)17379601CORUMView
5199Kinase maturation complex 1160.19 (3/16)14743216CORUMView
5212Kinase maturation complex 280.50 (4/8)14743216CORUMView
5234IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex50.60 (3/5)14743216CORUMView
5266TNF-alpha/NF-kappa B signaling complex 6140.36 (5/14)14743216CORUMView
5268TNF-alpha/NF-kappa B signaling complex 780.25 (2/8)14743216CORUMView
5269TNF-alpha/NF-kappa B signaling complex 860.50 (3/6)14743216CORUMView
5286TNF-alpha/NF-kappa B signaling complex 10100.30 (3/10)14743216CORUMView
5622HSP90-CIP1-FKBPL complex30.67 (2/3)15664193CORUMView
5716NOS3-HSP90 complex, VEGF induced20.50 (1/2)11425855CORUMView
5718NOS3-HSP90-AKT complex, VEGF induced30.33 (1/3)11425855CORUMView
6399DNAJC7-HSPA8-HSP90AA1 complex30.33 (1/3)12853476CORUMView
6402NMNAT2-HSP90 complex20.50 (1/2)27254664CORUMView
6512ILK-HSP90-CDC37 complex30.33 (1/3)15882985CORUMView
6591Hsp90-p23 complex20.50 (1/2)16403413CORUMView
7284GSK3B-HSP90AA1-PKM2 complex30.33 (1/3)29262861CORUMView
1056Kinase maturation complex 140.50 (2/4)NAhu.MAPView
2146Ribosome, cytoplasmic1430.13 (18/143)NAhu.MAPView
2985Ribosome, cytoplasmic1390.12 (16/139)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE102481mock_infected_18hRVFV_MP12_infected_18hdown-2.359.17e-19RNA-Seq data
GSE102481mock_infected_18hRVFV_ZH548_infected_18hdown-2.002.53e-13RNA-Seq data
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_WT_15hpidown-2.245.58e-07Microarray data
GSE50938polysomal_RNA_mock-infected_NHDFspolysomal_RNA_HCMV-infected_HNDFs_48h_post-infectionup1.722.36e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-2.272.13e-04Microarray data
GSE65574MCL001_mock_12hMCL001_dNSP16-MERS_12hdown-1.673.97e-03Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hdown-1.533.41e-02Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.686.95e-03Microarray data
GSE65574MCL001_mock_24hMCL001_dNSP16-MERS_24hdown-2.001.05e-02Microarray data
GSE65574MCL001_mock_24hMCL001_icMERS_24hdown-1.852.21e-02Microarray data
GSE65574MCL001_mock_7hMCL001_d3-5-MERS_7hdown-2.112.84e-02Microarray data
GSE65574MCL001_mock_7hMCL001_d4B-MERS_7hdown-2.064.87e-02Microarray data
GSE71766BEAS-2B_control_baselineBEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrsdown-1.563.67e-14Microarray data
GSE71766BEAS-2B_control_baselineBEAS-2B_InfluenzaVirus_72hrsdown-1.664.36e-15Microarray data
GSE71766BEAS-2B_control_baselineBEAS-2B_RhinoVirus_72hrsdown-1.675.34e-15Microarray data

Human tissue specific expression (TPM)

Small intestine: 255.7 Liver: 187.5 Gallbladder: 547.0 Duodenum: 182.6 Rectum: 329.0 Tonsil: 326.0 Stomach: 219.8 Salivary glanda: 148.1 Adipose tissue: 339.3 Lung: 386.4 Lymph node: 354.1 Pancreas: 46.5 Kidney: 452.8 Colon: 275.4 Appendix: 385.7 Smooth musle: 423.9 Breast: 512.1 Parathyroid gland: 829.4 Esophagus: 232.2 Heart muscle: 274.9 Spleen: 285.9 Skeletal muscle: 135.7 Bone marrow: 270.6 Skin: 247.0 Urinary bladder: 320.0 Cervix, uterine: 412.4 Endometrium: 379.6 Ovary: 340.2 Fallopian tube: 851.2 Seminal vesicle: 426.1 Prostate: 538.7 Epididymis: 368.7 Testis: 942.5 Placenta: 561.5 Thyroid gland: 356.1 Cerebral cortex: 1021.5 Adrenal gland: 545.0
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000080824
Gene description:Heat shock protein 90 alpha family class A member 1
Chromosome:14
Position102080738-102139699
Protein class:Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Cytosol