HVIDB-PPI detail

P07437 (TUBB)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: TBB5_HUMAN

UniProtID: P07437

Gene name(s): TUBB;TUBB5;OK/SW-cl.56

Protein name: Tubulin beta chain

Gene ID: 203068

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P07437-P27958	PHISTO,biogrid,HPIDB,VirusMentha	22810585	affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.999).	Show
DDI evidence:	yes (score 0.029).	Show
Machine learning evidence:	yes (score 0.311).

Combined Score: 0.999

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1335	SNW1 complex	18	0.17 (3/18)	12840015	CORUM	View
1400	ASCOM complex	7	0.14 (1/7)	12482968	CORUM	View
6703	TBCD-tubulin(alpha)-tubulin(beta) complex	3	0.33 (1/3)	28126905	CORUM	View
6713	TBCD-ARL2-tubulin(beta) complex	3	0.33 (1/3)	28126905	CORUM	View
6715	TBCD-ARL2-tubulin(beta)-TBCE complex	4	0.25 (1/4)	28126905	CORUM	View
1990	structural constituent of cytoskeleton,	5	0.20 (1/5)	NA	hu.MAP	View
3231	ribonucleoside binding	4	0.50 (2/4)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.87	4.86e-03	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.87	5.49e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.96	2.76e-04	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-2.72	2.28e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-2.68	1.93e-06	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.86	9.01e-05	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-1.78	1.78e-07	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-2.44	6.95e-08	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	up	2.84	5.27e-05	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	2.69	1.78e-04	Microarray data
GSE59226	Control	Virus_infection	down	-2.05	1.33e-04	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-2.53	8.32e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-3.76	5.28e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-4.32	4.54e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-3.23	2.09e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-3.85	2.84e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-2.39	2.50e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-2.97	2.08e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.15	2.67e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-3.39	1.02e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.46	7.89e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.50	2.90e-02	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.99	4.63e-14	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.82	1.06e-35	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-1.94	5.93e-03	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.25	1.79e-17	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.34	2.50e-11	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-2.76	2.45e-12	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.21	2.21e-10	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000196230
Gene description:	Tubulin beta class I
Chromosome:	6
Position	30720201-30725426
Protein class:	Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Microtubules