P06748 (NPM1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: NPM_HUMAN

UniProtID: P06748

Gene name(s): NPM1;NPM

Protein name: Nucleophosmin

Gene ID: 4869

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P06748-P27958PHISTO,biogrid,HPIDB,VirusMentha22810585affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.088). Show
Machine learning evidence: yes (score 0.296).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1223H2AX complex, isolated from cells without IR exposure130.38 (5/13)16522924CORUMView
1226H2AX complex I70.29 (2/7)16522924CORUMView
1227H2AX complex II100.30 (3/10)16522924CORUMView
1728CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex90.22 (2/9)14759373CORUMView
1729TLE1 corepressor complex (MASH1 promoter-corepressor complex)100.20 (2/10)15607978CORUMView
220ARF-Mule complex30.33 (1/3)15989956CORUMView
3055Nop56p-associated pre-rRNA complex1040.12 (12/104)12777385CORUMView
3135TLE1 corepressor complex (MASH1 promoter-corepressor complex)80.25 (2/8)15607978CORUMView
5154CTCF-nucleophosmin complex20.50 (1/2)14759373CORUMView
2146Ribosome, cytoplasmic1430.13 (18/143)NAhu.MAPView
2863PELP1-TEX10-WDR18 complex110.09 (1/11)NAhu.MAPView
3401MUS81-CDS1 complex60.17 (1/6)NAhu.MAPView
3793nucleic acid binding100.30 (3/10)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_DeltaE_15hpidown-2.237.71e-07Microarray data
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_WT_15hpidown-2.427.70e-07Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-2.451.06e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-2.271.34e-04Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.714.58e-02Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-2.665.66e-04Microarray data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hdown-1.651.63e-32RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 334.7 Liver: 187.8 Gallbladder: 602.0 Duodenum: 336.6 Rectum: 475.6 Tonsil: 700.3 Stomach: 300.7 Salivary glanda: 144.6 Adipose tissue: 359.7 Lung: 383.3 Lymph node: 901.2 Pancreas: 99.2 Kidney: 385.6 Colon: 351.0 Appendix: 596.8 Smooth musle: 683.4 Breast: 731.5 Parathyroid gland: 373.0 Esophagus: 537.5 Heart muscle: 231.7 Spleen: 449.3 Skeletal muscle: 95.8 Bone marrow: 500.3 Skin: 385.9 Urinary bladder: 550.8 Cervix, uterine: 697.5 Endometrium: 1114.5 Ovary: 1800.2 Fallopian tube: 913.1 Seminal vesicle: 454.6 Prostate: 547.2 Epididymis: 523.1 Testis: 534.7 Placenta: 601.9 Thyroid gland: 897.1 Cerebral cortex: 299.2 Adrenal gland: 422.7
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000181163
Gene description:Nucleophosmin
Chromosome:5
Position171387116-171411137
Protein class:Cancer-related genes, Disease related genes, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleus, Nucleoli