P06746 (POLB)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: DPOLB_HUMAN

UniProtID: P06746

Gene name(s): POLB

Protein name: DNA polymerase beta

Gene ID: 5423

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P06746-P27958PHISTO23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.028). Show
Machine learning evidence: yes (score 0.108).
Combined Score: 0.195


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1085DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC150.20 (1/5)16982218CORUMView
1086DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC150.20 (1/5)15260972CORUMView
21989-1-1-POLB complex40.25 (1/4)15314187CORUMView
362DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex40.25 (1/4)11163244CORUMView
2720DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex40.25 (1/4)NAhu.MAPView
2959DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex30.33 (1/3)NAhu.MAPView
4351DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex50.20 (1/5)NAhu.MAPView
4407DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex40.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE32155HTB-3_unifectedHTB-174_infectedup1.811.10e-03Microarray data

Human tissue specific expression (TPM)

Small intestine: 11.3 Liver: 16.7 Gallbladder: 26.6 Duodenum: 10.5 Rectum: 14.0 Tonsil: 19.6 Stomach: 12.9 Salivary glanda: 12.1 Adipose tissue: 11.0 Lung: 19.5 Lymph node: 22.4 Pancreas: 3.0 Kidney: 15.5 Colon: 11.7 Appendix: 17.8 Smooth musle: 15.1 Breast: 33.4 Parathyroid gland: 32.1 Esophagus: 27.4 Heart muscle: 17.0 Spleen: 22.7 Skeletal muscle: 28.8 Bone marrow: 32.3 Skin: 26.6 Urinary bladder: 27.9 Cervix, uterine: 16.2 Endometrium: 20.9 Ovary: 24.5 Fallopian tube: 20.5 Seminal vesicle: 15.2 Prostate: 36.0 Epididymis: 23.4 Testis: 92.7 Placenta: 15.4 Thyroid gland: 23.1 Cerebral cortex: 28.7 Adrenal gland: 22.2
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000070501
Gene description:DNA polymerase beta
Chromosome:8
Position42338454-42371808
Protein class:Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Vesicles