HVIDB-PPI detail

P06733 (ENO1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: ENOA_HUMAN

UniProtID: P06733

Gene name(s): ENO1;ENO1L1;MBPB1;MPB1

Protein name: Alpha-enolase

Gene ID: 2023

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P06733-P27958	PHISTO,biogrid,HPIDB,VirusMentha	22810585	affinity chromatography technology,tandem affinity purification

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.027).	Show
Machine learning evidence:	yes (score 0.289).

Combined Score: 0.995

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
50	YDJC-TPI1-TKT-PCMT1-ENO1	5	0.40 (2/5)	NA	hu.MAP	View
1084	TPI1-GAPDH-ENO1-PCMT1-TKT	5	0.40 (2/5)	NA	hu.MAP	View
1358	PMP2-FABP5-TAGLN3-HINT1-ENO1	5	0.20 (1/5)	NA	hu.MAP	View
2111	TPI1-ENO1	2	1.00 (2/2)	NA	hu.MAP	View
2591	PIN1-AUF1 complex	10	0.10 (1/10)	NA	hu.MAP	View
2908	DJ-1-SNCA complex, high molecular weight complex	6	0.17 (1/6)	NA	hu.MAP	View
3028	GPX4-ENO2-FABP5-HINT1-ENO1-TAGLN	6	0.17 (1/6)	NA	hu.MAP	View
3740	ENO1-CMPK1-TPI1	3	0.67 (2/3)	NA	hu.MAP	View
4202	NIT2-GAPDH-ENO1-TPI1-PCMT1	5	0.40 (2/5)	NA	hu.MAP	View
4253	ENO2-ENO1	2	0.50 (1/2)	NA	hu.MAP	View
4540	Sorcin homodimer complex	8	0.25 (2/8)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.64	6.18e-03	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.56	1.70e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.92	4.66e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.71	3.04e-04	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-1.92	1.46e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-1.88	2.54e-06	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-1.57	1.19e-07	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	1.58	3.77e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-2.36	5.65e-06	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	1.71	1.17e-02	Microarray data
GSE59226	Control	Virus_infection	down	-1.59	2.27e-04	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-1.79	6.20e-39	RNA-Seq data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-4.71	8.41e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.32	1.64e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-5.02	2.52e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-3.93	2.05e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-4.07	2.53e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_icMERS_7h	down	-2.80	1.69e-02	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-3.98	8.90e-04	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.67	2.57e-34	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-3.93	2.41e-190	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-1.65	1.70e-28	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-2.40	2.10e-06	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.33	1.03e-59	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.36	5.61e-54	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-3.21	7.70e-104	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-3.46	9.65e-151	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.05	4.63e-63	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000074800
Gene description:	Enolase 1
Chromosome:	1
Position	8861002-8879249
Protein class:	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Plasma membrane, Cytosol