P06454 (PTMA)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: PTMA_HUMAN

UniProtID: P06454

Gene name(s): PTMA;TMSA

Protein name: Prothymosin alpha

Gene ID: 5757

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P06454-P27958-PRO_0000037576HPIDB15607035two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.216).
Combined Score: 0.305


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
6984ProTalpha C2 complex40.25 (1/4)29106904CORUMView
6985ProTalpha C5 complex50.60 (3/5)29106904CORUMView
6987ProTalpha C7 complex30.33 (1/3)29106904CORUMView
6988ProTalpha C8 complex40.25 (1/4)29106904CORUMView
6989ProTalpha C9 complex20.50 (1/2)29106904CORUMView
7298ACTB-ANP32A-C1QBP-PSMA1-PTMA-PSMA1 complex60.50 (3/6)29106904CORUMView
7299ANP32A-ANP32B-PSMA3-PTMA-SLC25A5 complex50.40 (2/5)29106904CORUMView
138TTC14-SRSF1-PTMA30.33 (1/3)NAhu.MAPView
234PTMA-UVSSA20.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_DeltaE_15hpidown-2.325.97e-07Microarray data
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_WT_15hpidown-2.735.62e-07Microarray data
GSE65574MCL001_mock_24hMCL001_RFP-MERS_24hdown-1.898.91e-03Microarray data
GSE99298mock_infected_0hhRSV_NS1_Y125A_infected_96hdown-1.655.99e-05RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 876.7 Liver: 285.4 Gallbladder: 892.1 Duodenum: 703.1 Rectum: 1083.0 Tonsil: 1376.5 Stomach: 815.9 Salivary glanda: 238.6 Adipose tissue: 906.1 Lung: 928.2 Lymph node: 1620.2 Pancreas: 130.0 Kidney: 579.0 Colon: 998.1 Appendix: 1372.4 Smooth musle: 1033.1 Breast: 952.9 Parathyroid gland: 588.9 Esophagus: 787.2 Heart muscle: 197.5 Spleen: 1137.4 Skeletal muscle: 102.9 Bone marrow: 1441.6 Skin: 1090.6 Urinary bladder: 860.7 Cervix, uterine: 1169.0 Endometrium: 1489.4 Ovary: 1046.6 Fallopian tube: 1159.4 Seminal vesicle: 851.6 Prostate: 774.5 Epididymis: 845.8 Testis: 367.8 Placenta: 979.4 Thyroid gland: 1401.8 Cerebral cortex: 624.3 Adrenal gland: 584.5
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000187514
Gene description:Prothymosin, alpha
Chromosome:2
Position231706895-231713541
Protein class:Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleus, Cytosol