HVIDB-PPI detail

P06239 (LCK)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: LCK_HUMAN

UniProtID: P06239

Gene name(s): LCK

Protein name: Tyrosine-protein kinase Lck

Gene ID: 3932

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P06239-P27958	PHISTO,HPIDB,IntAct,VirusMentha	14993658	protein kinase assay

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.045).	Show
Machine learning evidence:	yes (score 0.283).

Combined Score: 0.999

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1067	CD8A-LCK complex	2	0.50 (1/2)	11034334	CORUM	View
2559	p56(LCK)-CAML complex	2	0.50 (1/2)	16111633	CORUM	View
2565	CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line)	4	0.75 (3/4)	7545683	CORUM	View
2879	CD20-LCK-FYN-p75/80 complex	3	0.67 (2/3)	7545683	CORUM	View
2944	Notch1-p56lck-PI3K complex	3	0.33 (1/3)	14583609	CORUM	View
2955	LCK-SLP76-PLC-gamma-1-LAT complex, pervanadate-activated	4	0.25 (1/4)	16938345	CORUM	View
6842	EphA1 receptor signaling complex	4	0.25 (1/4)	17634955	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84346	uninfected_control	HCV_infected_low_ISG	up	1.68	1.39e-09	RNA-Seq data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	6.81	7.51e-06	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-1.66	1.42e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	4.45	9.71e-05	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	up	4.65	1.76e-06	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	up	5.80	7.88e-06	Microarray data
GSE38941	nomal_liver	HBV-associated_acute_liver_failure_liver	up	2.06	1.68e-14	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	2.11	5.85e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	1.88	1.17e-05	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	up	3.28	4.98e-06	RNA-Seq data
GSE59226	Control	Virus_infection	up	3.16	8.92e-05	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	6.91	1.66e-02	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	6.62	1.87e-02	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	4.47	2.06e-02	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	9.87	7.16e-09	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	10.02	4.34e-09	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	10.24	3.38e-09	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	9.78	2.14e-07	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	7.96	2.05e-04	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
lymph node	125.9
tonsil	72.4

Ensembl ID:	ENSG00000182866
Gene description:	LCK proto-oncogene, Src family tyrosine kinase
Chromosome:	1
Position	32251239-32286165
Protein class:	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Golgi apparatus