HVIDB-PPI detail

P05787 (KRT8)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: K2C8_HUMAN

UniProtID: P05787

Gene name(s): KRT8;CYK8

Protein name: Keratin

Gene ID: 3856

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P05787-P27958-PRO_0000037566	HPIDB	15846844	anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.973).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.783).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
4125	KRT8-KRT17-KRT6A	3	0.33 (1/3)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-1.51	1.15e-03	RNA-Seq data
GSE68673	A549_uninfected	A549_infected	down	-1.64	3.76e-14	RNA-Seq data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.92	4.90e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.99	1.07e-04	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	down	-2.61	2.28e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-2.87	7.58e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_WT_7hpi	down	-1.53	1.40e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	2.66	1.60e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	6.94	3.06e-06	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	4.70	3.45e-05	Microarray data
GSE38941	nomal_liver	HBV-associated_acute_liver_failure_liver	up	1.77	4.54e-07	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.66	9.84e-03	Microarray data
GSE47937	mock_infected	A_WSN_33_infected	down	-1.73	1.56e-10	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group1	down	-1.80	2.08e-09	Microarray data
GSE47937	mock_infected	A_WSN_33_infected_with_group2	down	-1.92	2.78e-08	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-3.34	7.12e-08	Microarray data
GSE58914	NOK_cl1_uninfected	NOK_cl1_AkataBX-1_cl4_EBV+	down	-1.94	7.83e-04	Microarray data
GSE59226	Control	Virus_infection	down	-1.67	2.59e-04	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-1.62	5.60e-30	RNA-Seq data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	5.29	6.64e-26	RNA-Seq data
GSE99389	CD4+_mock_infected_4d	EBOV_infected_4d	up	3.85	4.78e-04	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.14	1.22e-20	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.55	2.23e-61	RNA-Seq data
GSE83259	NIKS_control	NIKS_HPV16	up	1.52	1.67e-04	Microarray data
GSE83259	NIKS_control	NIKS_HPV18	up	1.80	5.54e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	down	-2.86	7.22e-04	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
small intestine	1475.5

Ensembl ID:	ENSG00000170421
Gene description:	Keratin 8
Chromosome:	12
Position	52897187-52949954
Protein class:	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Intermediate filaments