HVIDB-PPI detail

P05412 (JUN)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: JUN_HUMAN

UniProtID: P05412

Gene name(s): JUN

Protein name: Transcription factor AP-1

Gene ID: 3725

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P05412-P27958	biogrid,HPIDB	12796506	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.271).

Combined Score: 0.521

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1816	JUN-TCF4-CTNNB1 complex	3	0.33 (1/3)	16007074	CORUM	View
2692	SMAD3-SMAD4-cJun-cFos complex	4	0.75 (3/4)	9732876	CORUM	View
2693	NFAT-JUN-FOS DNA-protein complex	3	1.00 (3/3)	9510247	CORUM	View
2694	ERG-JUN-FOS DNA-protein complex	3	0.67 (2/3)	11278640	CORUM	View
2695	ETS2-FOS-JUN complex	3	0.67 (2/3)	9334186	CORUM	View
2699	ESR1-JUN-GRIP1 complex	3	0.33 (1/3)	11477071	CORUM	View
2700	ESR1-JUN complex	2	0.50 (1/2)	11477071	CORUM	View
2708	SMAD3-SMAD4-cJUN complex	3	0.67 (2/3)	10220381	CORUM	View
6092	c-Jun-ATF3 complex	2	0.50 (1/2)	27751807	CORUM	View
6235	c-Fos-c-Jun-SAF-1 complex	3	0.67 (2/3)	19028685	CORUM	View
6975	JUN-FBW7-PRR7 complex	3	0.67 (2/3)	27458189	CORUM	View
585	c-Jun-ATF3 complex	6	0.33 (2/6)	NA	hu.MAP	View
1030	c-Jun-ATF3 complex	6	0.17 (1/6)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	6.91	1.05e-61	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	7.04	7.35e-56	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	2.31	1.89e-18	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	3.01	3.64e-12	RNA-Seq data
GSE64677	mock_infected_96h	m15_virus_infected_96h	up	2.01	5.43e-32	RNA-Seq data
GSE68673	A549_uninfected	A549_infected	up	1.85	4.44e-07	RNA-Seq data
GSE69602	cytosol_unifected	cytosol_DENV2_infected_40h	up	4.02	8.20e-03	RNA-Seq data
GSE69602	ER_unifected	ER_DENV2_infected_40h	up	4.33	6.20e-07	RNA-Seq data
GSE84285	A549_mock_infected_24h	A549_Dengue_virus_infected_24h	up	1.62	3.99e-67	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	up	2.84	3.96e-154	RNA-Seq data
GSE18906	CD36+EPC_Control_12h	CD36+EPC-NS1_transduced_12h	down	-1.55	3.34e-03	Microarray data
GSE19345	Mock_infected	HCMV_infected_12h	down	-1.59	2.53e-04	Microarray data
GSE19345	Mock_infected	HCMV_infected_24h	down	-2.39	4.19e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	up	1.68	5.78e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	2.03	5.18e-04	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	up	1.70	3.21e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_WT_7hpi	up	1.79	2.01e-05	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	1.85	8.88e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	2.02	8.12e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	3.64	6.92e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	4.22	1.33e-03	Microarray data
GSE36553	mock_infection	H1N1_infection_48h	up	1.87	4.50e-03	Microarray data
GSE36555	mock_infection	H1N1_infection_48h	up	1.87	4.50e-03	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	up	2.47	3.78e-05	Microarray data
GSE47865	mock_infected	SV_infected	up	2.75	3.61e-10	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	down	-2.85	6.72e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Anhui01_pCalu3_12h	up	2.66	4.88e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	3.08	5.23e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	1.92	3.19e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	2.02	7.43e-07	Microarray data
GSE49985	HEK293T_cells_control	HEK293T_cells_infected_24h	up	2.72	1.46e-05	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-1.51	3.27e-04	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.32	8.33e-04	Microarray data
GSE53103	HeLa_shscr	HeLa_shscr_+SV_6h	up	1.89	2.37e-05	Microarray data
GSE54293	NCI-H1666_mock	NCI-H1666_infected	up	2.51	1.73e-07	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	up	3.07	2.61e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	up	3.36	2.26e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_dNSP16-MERS_12h	up	2.99	2.00e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	up	2.83	1.98e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	3.94	2.92e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	3.47	1.66e-04	Microarray data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	2.11	8.82e-10	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	3.83	1.13e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	3.13	1.65e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	up	3.47	4.36e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	4.21	6.10e-03	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	2.52	9.26e-12	Microarray data
GSE67198	uninfected_control	150HA_u_per_mL_Sev_infected	up	1.73	1.61e-06	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_2hrs	up	2.27	1.44e-12	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_4hrs	up	2.10	1.46e-12	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	1.67	3.28e-26	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_2hrs	up	2.21	2.00e-11	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_4hrs	up	2.13	5.05e-13	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_2hrs	up	2.25	2.15e-13	Microarray data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-1.99	3.16e-31	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_4hrs	up	2.10	2.38e-13	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-1.72	3.55e-23	RNA-Seq data
GSE87463	mock-infected_12h	HRV-infected_12h	up	1.52	2.13e-03	Microarray data
GSE8961	Mock_infection	HMPV_infection_12h	up	2.10	8.39e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_24h	up	2.80	1.63e-07	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	2.98	7.75e-04	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	up	3.65	2.58e-07	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000177606
Gene description:	Jun proto-oncogene, AP-1 transcription factor subunit
Chromosome:	1
Position	58780788-58784327
Protein class:	Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Transcription factors
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm