HVIDB-PPI detail

P05155 (SERPING1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: IC1_HUMAN

UniProtID: P05155

Gene name(s): SERPING1;C1IN;C1NH

Protein name: Plasma protease C1 inhibitor

Gene ID: 710

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P05155-P27958	PHISTO	10570951	Other Methods

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.193).

Combined Score: 0.230

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84188	mock_infected_1d	EBOV_infected_1d	up	3.71	4.46e-02	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	4.04	9.81e-13	RNA-Seq data
GSE84897	MKN7_WT_control	MKN7_EBV_infected	down	-5.08	2.03e-04	RNA-Seq data
GSE11348	2d_Postinfection_control	2d_Postinfection_RV16	up	2.02	2.62e-04	Microarray data
GSE14816	TB40E_mock	TB40E_TB	up	4.20	1.53e-04	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	6.63	5.52e-05	Microarray data
GSE30550	peripheral_blood_00h	peripheral_blood_053h	up	1.52	3.32e-02	Microarray data
GSE30550	peripheral_blood_00h	peripheral_blood_060h	up	1.73	1.88e-02	Microarray data
GSE30550	peripheral_blood_00h	peripheral_blood_069h	up	1.69	1.08e-02	Microarray data
GSE30550	peripheral_blood_00h	peripheral_blood_077h	up	1.76	1.52e-02	Microarray data
GSE30550	peripheral_blood_00h	peripheral_blood_084h	up	1.65	1.93e-02	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	1.74	1.59e-02	Microarray data
GSE31524	H5N2-F59_Mock_infection	H5N2-F59_infection_10h	up	1.88	6.79e-06	Microarray data
GSE32140-GPL570	infant_healthy_control_for_influenza	infant_influenza	up	1.72	1.16e-02	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	3.31	3.36e-05	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	3.24	1.09e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	1.81	1.30e-02	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-5.53	3.41e-07	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	down	-5.89	2.99e-06	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-4.77	2.88e-06	Microarray data
GSE38941	nomal_liver	HBV-associated_acute_liver_failure_liver	down	-1.82	1.37e-14	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.92	7.29e-04	Microarray data
GSE53543	uninfected_control	RV_infected	up	1.56	3.17e-85	Microarray data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	5.44	6.08e-59	RNA-Seq data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	2.27	1.30e-03	RNA-Seq data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	down	-3.47	2.36e-08	RNA-Seq data
GSE99389	CD4+_mock_infected_4d	LPS_infected_4d	down	-3.51	6.78e-05	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	5.32	5.06e-04	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	4.27	1.78e-03	Microarray data
GSE68503	empty_vector_control	tumor-derived_LT339+sT	down	-1.75	3.48e-02	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	2.07	6.36e-07	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	1.53	5.11e-04	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	2.66	3.26e-24	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	3.35	1.25e-21	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	1.54	3.86e-08	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	1.71	1.39e-08	RNA-Seq data
GSE73072	H1N1_DEE3_0h	H1N1_DEE3_77h	up	1.62	4.28e-03	Microarray data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	1.67	2.62e-03	RNA-Seq data
GSE73072	H1N1_DEE3_-21h	H1N1_DEE3_77h	up	1.58	7.28e-03	Microarray data
GSE73072	H3N2_DEE2_0h	H3N2_DEE2_53h	up	1.69	3.79e-02	Microarray data
GSE73072	H3N2_DEE2_0h	H3N2_DEE2_77h	up	1.98	1.64e-02	Microarray data
GSE73072	H3N2_DEE2_0h	H3N2_DEE2_84h	up	1.82	2.10e-02	Microarray data
GSE73072	H3N2_DEE2_0h	H3N2_DEE2_94h	up	1.62	1.99e-02	Microarray data
GSE73072	H3N2_DEE2_-23h	H3N2_DEE2_77h	up	1.73	4.17e-02	Microarray data
GSE73072	H3N2_DEE5_-30h	H3N2_DEE5_58h	up	1.91	2.79e-03	Microarray data
GSE73072	H3N2_DEE5_-30h	H3N2_DEE5_66h	up	1.65	7.19e-03	Microarray data
GSE73072	RSV_DEE1_0h	RSV_DEE1_108h	up	1.50	1.08e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	2.24	3.19e-03	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	3.08	9.99e-05	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	2.23	1.52e-11	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000149131
Gene description:	Serpin family G member 1
Chromosome:	11
Position	57597387-57614853
Protein class:	Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location: