P04637 (TP53)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: P53_HUMAN

UniProtID: P04637

Gene name(s): TP53;P53

Protein name: Cellular tumor antigen p53

Gene ID: 7157

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P04637-P27958-PRO_0000037566HPIDB12730672anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.793).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2179CNS-P53 complex90.11 (1/9)11285227CORUMView
2224MSH2/6-BLM-p53-RAD51 complex50.20 (1/5)15064730CORUMView
2670Er-alpha-p53-hdm2 complex30.33 (1/3)10766163CORUMView
2678FOXO3-TP53 complex, oxidative stress stimulated20.50 (1/2)14976264CORUMView
2679p53-SP1 complex20.50 (1/2)15674334CORUMView
2681p53 homotetramer complex11.00 (1/1)15674341CORUMView
2821hSIR2-p53 complex20.50 (1/2)11672523CORUMView
2842DAXX-Axin-p53-HIPK2 complex40.25 (1/4)17210684CORUMView
2844Axin-p53-HIPK2 complex30.33 (1/3)15526030CORUMView
3170Daxx-Axin-p53 complex30.33 (1/3)17210684CORUMView
3172NUMB-TP53-MDM2 complex30.33 (1/3)18172499CORUMView
5288P53-BARD1-KU70 complex30.33 (1/3)15782130CORUMView
5331YY1-MDM2-p53 complex30.67 (2/3)15210108CORUMView
577FHL2-p53-HIPK2 complex30.33 (1/3)16343438CORUMView
5811p53-BCL2 complex20.50 (1/2)12667443CORUMView
5812p53-BCL2 complex20.50 (1/2)12667443CORUMView
6188STIP-USP7-p53 complex30.33 (1/3)26460617CORUMView
6300CDKN1A-TP53-CDK1-PCNA complex30.67 (2/3)7624128CORUMView
65773M complex70.14 (1/7)24793695CORUMView
7180p53-MDM2 complex20.50 (1/2)22487680CORUMView
7420TP53-TSPY1-USP7 complex30.33 (1/3)29748603CORUMView
98p300-MDM2-p53 protein complex30.67 (2/3)11070080CORUMView
8283M complex30.33 (1/3)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE28166mock_infected_24hVN1203_infected_24hdown-2.076.25e-03Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infecteddown-7.032.47e-07Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup6.336.02e-07Microarray data
GSE32155HTB-4_unifectedHTB-174_infectedup3.427.64e-06Microarray data
GSE45042ELC001_mock_infected_24hECL001_EMC_infected_24hdown-3.188.35e-05Microarray data
GSE48121PANC-1_cells_controlPANC-1_cells_GLV-1h153_infection_6hdown-2.613.79e-07Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-1.923.23e-06Microarray data
GSE8961Mock_infectionHMPV_infection_72hdown-1.621.62e-04Microarray data

Human tissue specific expression (TPM)

Small intestine: 23.0 Liver: 7.8 Gallbladder: 20.8 Duodenum: 19.5 Rectum: 30.2 Tonsil: 41.0 Stomach: 22.7 Salivary glanda: 6.9 Adipose tissue: 15.9 Lung: 22.6 Lymph node: 40.2 Pancreas: 3.9 Kidney: 11.1 Colon: 28.6 Appendix: 36.9 Smooth musle: 36.0 Breast: 27.3 Parathyroid gland: 15.4 Esophagus: 32.4 Heart muscle: 6.0 Spleen: 43.3 Skeletal muscle: 3.2 Bone marrow: 13.0 Skin: 46.4 Urinary bladder: 27.6 Cervix, uterine: 26.0 Endometrium: 41.0 Ovary: 33.9 Fallopian tube: 50.3 Seminal vesicle: 21.2 Prostate: 28.5 Epididymis: 16.0 Testis: 19.9 Placenta: 33.9 Thyroid gland: 29.6 Cerebral cortex: 22.9 Adrenal gland: 13.4
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000141510
Gene description:Tumor protein p53
Chromosome:17
Position7661779-7687550
Protein class:Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm