Human protein: P53_HUMAN
UniProtID: P04637
Gene name(s): TP53;P53
Protein name: Cellular tumor antigen p53
Gene ID: 7157
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P04637-P27958 | PHISTO,biogrid,HPIDB | 16322229,12379483 | affinity chromatography technology,fluorescence microscopy |
| Interolog evidence: | none/insignificant. | |
| DDI evidence: | yes (score 0.035). | Show |
| Machine learning evidence: | yes (score 0.509). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 2179 | CNS-P53 complex | 9 | 0.11 (1/9) | 11285227 | CORUM | View |
| 2224 | MSH2/6-BLM-p53-RAD51 complex | 5 | 0.20 (1/5) | 15064730 | CORUM | View |
| 2670 | Er-alpha-p53-hdm2 complex | 3 | 0.33 (1/3) | 10766163 | CORUM | View |
| 2678 | FOXO3-TP53 complex, oxidative stress stimulated | 2 | 0.50 (1/2) | 14976264 | CORUM | View |
| 2679 | p53-SP1 complex | 2 | 0.50 (1/2) | 15674334 | CORUM | View |
| 2681 | p53 homotetramer complex | 1 | 1.00 (1/1) | 15674341 | CORUM | View |
| 2821 | hSIR2-p53 complex | 2 | 0.50 (1/2) | 11672523 | CORUM | View |
| 2842 | DAXX-Axin-p53-HIPK2 complex | 4 | 0.25 (1/4) | 17210684 | CORUM | View |
| 2844 | Axin-p53-HIPK2 complex | 3 | 0.33 (1/3) | 15526030 | CORUM | View |
| 3170 | Daxx-Axin-p53 complex | 3 | 0.33 (1/3) | 17210684 | CORUM | View |
| 3172 | NUMB-TP53-MDM2 complex | 3 | 0.33 (1/3) | 18172499 | CORUM | View |
| 5288 | P53-BARD1-KU70 complex | 3 | 0.33 (1/3) | 15782130 | CORUM | View |
| 5331 | YY1-MDM2-p53 complex | 3 | 0.67 (2/3) | 15210108 | CORUM | View |
| 577 | FHL2-p53-HIPK2 complex | 3 | 0.33 (1/3) | 16343438 | CORUM | View |
| 5811 | p53-BCL2 complex | 2 | 0.50 (1/2) | 12667443 | CORUM | View |
| 5812 | p53-BCL2 complex | 2 | 0.50 (1/2) | 12667443 | CORUM | View |
| 6188 | STIP-USP7-p53 complex | 3 | 0.33 (1/3) | 26460617 | CORUM | View |
| 6300 | CDKN1A-TP53-CDK1-PCNA complex | 3 | 0.67 (2/3) | 7624128 | CORUM | View |
| 6577 | 3M complex | 7 | 0.14 (1/7) | 24793695 | CORUM | View |
| 7180 | p53-MDM2 complex | 2 | 0.50 (1/2) | 22487680 | CORUM | View |
| 7420 | TP53-TSPY1-USP7 complex | 3 | 0.33 (1/3) | 29748603 | CORUM | View |
| 98 | p300-MDM2-p53 protein complex | 3 | 0.67 (2/3) | 11070080 | CORUM | View |
| 828 | 3M complex | 3 | 0.33 (1/3) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE28166 | mock_infected_24h | VN1203_infected_24h | down | -2.07 | 6.25e-03 | Microarray data |
| GSE32155 | CRL-5800_unifected | CRL-5807_infected | down | -7.03 | 2.47e-07 | Microarray data |
| GSE32155 | CRL-5810_unifected | CRL-1472_infected | up | 6.33 | 6.02e-07 | Microarray data |
| GSE32155 | HTB-4_unifected | HTB-174_infected | up | 3.42 | 7.64e-06 | Microarray data |
| GSE45042 | ELC001_mock_infected_24h | ECL001_EMC_infected_24h | down | -3.18 | 8.35e-05 | Microarray data |
| GSE48121 | PANC-1_cells_control | PANC-1_cells_GLV-1h153_infection_6h | down | -2.61 | 3.79e-07 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_VN1203_pCalu3_24h | down | -1.92 | 3.23e-06 | Microarray data |
| GSE8961 | Mock_infection | HMPV_infection_72h | down | -1.62 | 1.62e-04 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000141510 |
| Gene description: | Tumor protein p53 |
| Chromosome: | 17 |
| Position | 7661779-7687550 |
| Protein class: | Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleoplasm |