HVIDB-PPI detail

P04275 (VWF)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: VWF_HUMAN

UniProtID: P04275

Gene name(s): VWF;F8VWF

Protein name: von Willebrand factor

Gene ID: 7450

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P04275-P27958	biogrid,HPIDB	18985028	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.282).

Combined Score: 0.568

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
6297	vWF-GPIb complex	2	0.50 (1/2)	7887899	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE83525	B19_NS1mTAD2_unexpressed	B19_NS1mTAD2_expressed	down	-1.68	3.85e-04	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	down	-2.65	3.70e-06	RNA-Seq data
GSE84897	MKN7_WT_control	MKN7_EBV_infected	down	-7.22	2.93e-06	RNA-Seq data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-2.26	5.54e-03	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.68	9.05e-05	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	up	2.06	2.68e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	up	1.86	4.73e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.60	4.03e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	down	-4.43	6.02e-05	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	5.92	1.04e-06	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	4.72	9.41e-08	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	down	-2.50	1.19e-07	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	down	-1.89	3.69e-03	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-2.95	1.32e-24	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-1.81	1.27e-02	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-1.67	1.23e-13	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.50	2.38e-23	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-3.24	1.51e-29	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.26	2.66e-12	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-1.58	4.47e-07	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
adipose tissue	155.1

Ensembl ID:	ENSG00000110799
Gene description:	Von Willebrand factor
Chromosome:	12
Position	5948874-6124770
Protein class:	Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location: