P02788 (LTF)

Homo sapiens

P27958-PRO_0000037573 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: TRFL_HUMAN

UniProtID: P02788

Gene name(s): LTF;GIG12;LF

Protein name: Lactotransferrin

Gene ID: 4057

HDF/HRF: NA

Virus protein: Serine protease NS3(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037573

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P02788-P27958-PRO_0000037573HPIDB25193851pull down

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.005). Show
Machine learning evidence: yes (score 0.687).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
6823CPu2013LFu2013MPO complex30.33 (1/3)17511605CORUMView
6824CP-LF complex20.50 (1/2)17511605CORUMView
3570CP-LF complex20.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE72925NormalPVANup2.331.82e-03Microarray data
GSE32140-GPL570infant_healthy_control_for_influenzainfant_influenzaup1.922.69e-02Microarray data
GSE32140-GPL570infant_healthy_control_for_rsvinfant_rsvup2.651.51e-02Microarray data
GSE32155CRL-5800_unifectedCRL-1472_infectedup2.335.38e-06Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup1.933.51e-03Microarray data
GSE32155HTB-3_unifectedHTB-174_infecteddown-2.141.36e-02Microarray data
GSE38900-GPL6884Dallas_healthy_controlDallas_RSV_acute_infectionup1.592.94e-03Microarray data
GSE38900-GPL6884Dallas_healthy_matched_controlDallas_HRV_acute_infectionup1.922.58e-03Microarray data
GSE97672-GPL16791MDM-315_H1N1_MOI0_18hMDM-315_H1N1_MOI2_18hup7.152.82e-03RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hup8.736.89e-06RNA-Seq data
GSE97672-GPL16791MDM-513_H5N1_MOI0_06hMDM-513_H5N1_MOI2_06hup6.682.33e-02RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hup2.902.68e-02RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 1.8 Liver: 1.7 Gallbladder: 12.3 Duodenum: 1.2 Rectum: 2.4 Tonsil: 311.0 Stomach: 303.2 Salivary glanda: 450.3 Adipose tissue: 5.7 Lung: 10.5 Lymph node: 10.2 Pancreas: 2.6 Kidney: 7.0 Colon: 2.7 Appendix: 48.3 Smooth musle: 2.9 Breast: 389.7 Parathyroid gland: 0.4 Esophagus: 4.8 Heart muscle: 2.0 Spleen: 30.5 Skeletal muscle: 0.4 Bone marrow: 2804.3 Skin: 14.1 Urinary bladder: 3.2 Cervix, uterine: 1030.7 Endometrium: 6.6 Ovary: 0.5 Fallopian tube: 2.2 Seminal vesicle: 532.6 Prostate: 258.1 Epididymis: 191.6 Testis: 0.7 Placenta: 4.4 Thyroid gland: 10.8 Cerebral cortex: 5.0 Adrenal gland: 1.1
Expression value is measured by Transcripts Per Million (TPM)
Tissue enhanced:
TissueExpression (TPM)
bone marrow 2804.3
cervix, uterine 1030.7
Ensembl ID:ENSG00000012223
Gene description:Lactotransferrin
Chromosome:3
Position46435645-46485234
Protein class:Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Evidence:Evidence at protein level
Subcellular location: