P02675 (FGB)
Homo sapiensP27958-PRO_0000037566 (NA)
Hepatitis C virus genotype 1a (isolate H) (HCV)Human protein: FIBB_HUMAN
UniProtID: P02675
Gene name(s): FGB
Protein name: Fibrinogen beta chain
Gene ID: 2244
HDF/HRF: NA
Virus protein: Core protein p21(POLG_HCVH) (HCV-H)
UniProtID: P27958-PRO_0000037566
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| P02675-P27958-PRO_0000037566 | HPIDB | 20162731 | bimolecular fluorescence complementation |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 6417 | Fibrinogen complex | 3 | 0.33 (1/3) | 19296670 | CORUM | View |
| 1728 | DDX19B-ALOX15-IL36RN-FGB-APOBEC3A-FCGBP | 6 | 0.17 (1/6) | NA | hu.MAP | View |
| 3843 | Fibrinogen complex | 6 | 0.17 (1/6) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE38941 | nomal_liver | HBV-associated_acute_liver_failure_liver | down | -4.11 | 1.40e-03 | Microarray data |
| GSE45042 | ELC001_mock_infected_24h | ECL001_EMC_infected_24h | up | 6.51 | 3.28e-05 | Microarray data |
| GSE65123 | healthy_seronegative_control | HCV_infected | up | 2.53 | 4.26e-02 | Microarray data |
| GSE99298 | mock_infected_0h | hRSV_WT_infected_96h | down | -1.89 | 1.65e-05 | RNA-Seq data |
| GSE89008 | HTBE_H1N1_MOI0_mock_infected_24h | HTBE_H1N1_MOI5_infected_24h | down | -6.96 | 5.76e-03 | RNA-Seq data |
| GSE89008 | HTBE_H1N1_MOI0_mock_infected_18h | HTBE_H1N1_MOI5_infected_18h | up | 23.66 | 3.51e-05 | RNA-Seq data |
| GSE8961 | Mock_infection | HMPV_infection_72h | down | -1.65 | 1.53e-04 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Tissue enriched:
| Tissue | Expression (TPM) |
|---|---|
| liver | 10006.0 |
| Ensembl ID: | ENSG00000171564 |
| Gene description: | Fibrinogen beta chain |
| Chromosome: | 4 |
| Position | 154562956-154571086 |
| Protein class: | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Endoplasmic reticulum |