HVIDB-PPI detail

P02649 (APOE)

Homo sapiens

P27958-PRO_0000037572 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: APOE_HUMAN

UniProtID: P02649

Gene name(s): APOE

Protein name: Apolipoprotein E

Gene ID: 348

HDF/HRF: NA

Virus protein: Protease NS2-3(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037572

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P02649-P27958-PRO_0000037572	HPIDB	25122793	anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.002).	Show
Machine learning evidence:	yes (score 0.664).

Combined Score: 0.999

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	7.02	8.96e-03	RNA-Seq data
GSE79032	uninfected	KSHV_infected	down	-5.65	4.00e-02	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.86	3.59e-02	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	down	-1.58	8.33e-06	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-5.34	1.61e-06	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-6.04	8.03e-07	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-2.81	2.25e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	1.74	5.56e-07	Microarray data
GSE53543	uninfected_control	RV_infected	down	-2.00	6.84e-25	Microarray data
GSE93385	G010_mock_infected	G010_ZIKV_infected	up	1.78	3.70e-17	RNA-Seq data
GSE97949	uninfected_0h	H7N9_infected_7h	up	3.29	2.77e-15	RNA-Seq data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.90	1.96e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-1.55	1.67e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-2.89	1.63e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-2.12	1.63e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.47	6.39e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-3.45	7.91e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	down	-4.22	1.64e-02	RNA-Seq data
GSE99389	CD4+_mock_infected_4d	LPS_infected_4d	down	-5.74	4.95e-05	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	down	-2.98	3.46e-02	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	down	-2.98	3.32e-02	Microarray data
GSE68503	empty_vector_control	tumor-derived_LT339+sT	up	4.00	4.78e-02	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.76	1.86e-09	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	down	-1.83	1.06e-07	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	down	-1.68	1.35e-04	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.84	1.12e-19	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.53	6.92e-81	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.61	2.03e-10	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-2.38	2.77e-45	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.41	5.93e-23	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-1.71	1.32e-49	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000130203
Gene description:	Apolipoprotein E
Chromosome:	19
Position	44905754-44909393
Protein class:	Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location:	Vesicles