P01112 (HRAS)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: RASH_HUMAN

UniProtID: P01112

Gene name(s): HRAS;HRAS1

Protein name: GTPase HRas

Gene ID: 3265

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
P01112-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.771).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1700ABL2-HRAS-RIN1 complex30.33 (1/3)15886098CORUMView
5922RAF1-RAS complex, EGF induced20.50 (1/2)16364920CORUMView
6219DGKZ-RASGRP1-HRAS complex30.33 (1/3)11257115CORUMView
7243AURKA-HRAS-RAF1 complex30.67 (2/3)28177880CORUMView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE27702control_macrophagesFPV-infected_macrophagesup1.944.06e-03Microarray data
GSE28166mock_infected_24hVN1203_infected_24hup1.972.63e-04Microarray data
GSE32155CRL-5800_unifectedCRL-1472_infectedup2.657.05e-05Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infecteddown-1.721.40e-03Microarray data
GSE32155HTB-3_unifectedHTB-174_infecteddown-2.291.36e-03Microarray data
GSE32155HTB-4_unifectedHTB-174_infecteddown-3.733.05e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hup1.501.26e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-2.091.81e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-2.153.41e-05Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hdown-1.728.01e-03Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-2.018.74e-04Microarray data

Human tissue specific expression (TPM)

Small intestine: 5.0 Liver: 1.7 Gallbladder: 6.3 Duodenum: 5.0 Rectum: 3.3 Tonsil: 4.5 Stomach: 3.6 Salivary glanda: 2.5 Adipose tissue: 8.4 Lung: 7.4 Lymph node: 5.5 Pancreas: 1.1 Kidney: 4.4 Colon: 5.3 Appendix: 7.3 Smooth musle: 6.7 Breast: 6.0 Parathyroid gland: 10.4 Esophagus: 15.0 Heart muscle: 12.2 Spleen: 4.8 Skeletal muscle: 13.2 Bone marrow: 1.7 Skin: 24.5 Urinary bladder: 6.6 Cervix, uterine: 6.0 Endometrium: 4.4 Ovary: 4.8 Fallopian tube: 7.1 Seminal vesicle: 9.7 Prostate: 8.8 Epididymis: 5.8 Testis: 5.9 Placenta: 8.3 Thyroid gland: 7.3 Cerebral cortex: 25.0 Adrenal gland: 8.3
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000174775
Gene description:HRas proto-oncogene, GTPase
Chromosome:11
Position532242-537287
Protein class:Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Evidence:Evidence at protein level
Subcellular location: