HVIDB-PPI detail

P01100 (FOS)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: FOS_HUMAN

UniProtID: P01100

Gene name(s): FOS;G0S7

Protein name: Proto-oncogene c-Fos

Gene ID: 2353

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P01100-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.745).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2692	SMAD3-SMAD4-cJun-cFos complex	4	0.75 (3/4)	9732876	CORUM	View
2693	NFAT-JUN-FOS DNA-protein complex	3	1.00 (3/3)	9510247	CORUM	View
2694	ERG-JUN-FOS DNA-protein complex	3	0.67 (2/3)	11278640	CORUM	View
2695	ETS2-FOS-JUN complex	3	0.67 (2/3)	9334186	CORUM	View
6235	c-Fos-c-Jun-SAF-1 complex	3	0.67 (2/3)	19028685	CORUM	View
585	c-Jun-ATF3 complex	6	0.33 (2/6)	NA	hu.MAP	View
1615	FOS-JUNB-JUND-ADCK5-BATF3	5	0.20 (1/5)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	3.02	1.21e-03	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	3.66	1.45e-09	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	5.62	1.13e-38	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	5.36	4.10e-24	RNA-Seq data
GSE102481	mock_infected_9h	RVFV_MP12_infected_9h	up	3.52	1.11e-03	RNA-Seq data
GSE102481	mock_infected_9h	RVFV_ZH548_infected_9h	up	3.08	3.07e-04	RNA-Seq data
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	1.74	7.94e-04	RNA-Seq data
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	2.10	3.06e-05	RNA-Seq data
GSE64677	mock_infected_72h	WT_infected_72h	up	2.91	1.33e-05	RNA-Seq data
GSE64677	mock_infected_96h	m15_virus_infected_96h	up	3.30	6.57e-04	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	up	1.71	1.48e-04	RNA-Seq data
GSE84346	uninfected_control	HCV_infected_high_ISG	up	1.74	9.62e-03	RNA-Seq data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	2.46	6.46e-04	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	2.65	6.26e-05	Microarray data
GSE18906	CD36+EPC_Control_12h	CD36+EPC-NS1_transduced_12h	down	-2.13	3.34e-03	Microarray data
GSE19345	Mock_infected	HCMV_infected_12h	down	-2.22	1.88e-04	Microarray data
GSE19345	Mock_infected	HCMV_infected_24h	down	-2.62	5.24e-05	Microarray data
GSE24238	Mock_24h	HCMV_24h	down	-2.00	1.16e-02	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	up	4.62	2.20e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	up	5.50	8.83e-05	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	5.20	1.17e-05	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_DeltaE_24h	up	1.96	2.35e-04	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_DeltaE_65h	up	3.53	5.19e-06	Microarray data
GSE30589	MA-104_Mock_infected_0h	MA-104_SARS-Cov_WT_65h	up	1.67	6.38e-05	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_DeltaE_15hpi	up	5.28	2.28e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_15hpi	Vero_E6_SARS-Cov_WT_15hpi	up	2.36	1.50e-06	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_DeltaE_7hpi	up	3.41	3.91e-07	Microarray data
GSE30589	Vero_E6_Mock_infected_7hpi	Vero_E6_SARS-Cov_WT_7hpi	up	4.32	5.49e-07	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	down	-1.79	1.11e-02	Microarray data
GSE31518	A549_mock_infection	A549_pH1N1_infection_10h	up	2.26	2.98e-05	Microarray data
GSE31518	A549_mock_infection	A549_pH1N1_infection_2h	up	2.10	2.65e-04	Microarray data
GSE31524	H1N1_Mock_infection_10h	H1N1_infection_10h	up	1.62	1.75e-05	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	1.59	1.82e-03	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	2.56	2.98e-02	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	up	3.67	2.44e-02	Microarray data
GSE36553	mock_infection	H1N1_infection_0h	up	2.31	4.90e-03	Microarray data
GSE36555	mock_infection	H1N1_infection_0h	up	2.31	4.90e-03	Microarray data
GSE43794	NPCs_jCV_infection_0h	NPCs_jCV_infection_1h	up	1.53	1.73e-10	Microarray data
GSE45042	ELC001_mock_infected_12h	ECL001_EMC_infected_12h	up	1.79	4.10e-02	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.64	2.50e-03	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	down	-2.07	3.86e-02	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	1.51	6.62e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	2.13	2.05e-07	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.83	2.77e-02	Microarray data
GSE53103	HeLa_no_infection	Hela_SV_12h	down	-2.48	1.36e-06	Microarray data
GSE53103	HeLa_no_infection	Hela_SV_6h	down	-2.42	5.10e-06	Microarray data
GSE53103	Namalwa_no_infection	Namalwa_SV_12h	up	1.51	1.96e-05	Microarray data
GSE54293	NCI-H1666_mock	NCI-H1666_infected	up	2.19	4.40e-07	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_12h	down	-1.74	5.38e-03	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_18h	down	-1.87	1.96e-02	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_6h	down	-2.07	2.76e-03	Microarray data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	1.55	1.46e-07	RNA-Seq data
GSE59226	Control	Virus_infection	up	5.39	1.16e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	3.61	1.14e-02	Microarray data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	down	-2.08	8.28e-04	RNA-Seq data
GSE65699	PRE_mock	PRE_infection_RKAA	up	4.10	9.37e-14	Microarray data
GSE87750-GPL16791	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	up	2.83	1.68e-07	RNA-Seq data
GSE87750-GPL21290	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	up	2.81	1.20e-02	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	down	-4.68	2.46e-04	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	down	-2.82	1.36e-02	Microarray data
GSE87750-GPL16791	hPN_mock_infected	hPN_ZIKV-PRVABC59_infected	up	3.76	8.89e-19	RNA-Seq data
GSE67345	C33a_1ug_per_ml_-doxycyclin_48h	C33a_1ug_per_ml_+doxycyclin_48h	up	1.72	2.34e-03	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	2.40	4.36e-41	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	2.86	1.52e-42	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	down	-1.60	3.36e-19	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	2.40	7.52e-28	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_2hrs	up	3.24	1.41e-14	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	3.36	3.14e-78	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_4hrs	up	3.98	1.66e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_8hrs	up	1.63	5.01e-12	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_2hrs	up	3.22	2.52e-15	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_4hrs	up	4.03	1.66e-16	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	2.15	2.33e-04	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_8hrs	up	1.56	1.53e-11	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	2.52	2.26e-45	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_2hrs	up	3.17	4.19e-15	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_4hrs	up	3.95	1.37e-16	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-1.66	6.16e-15	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_8hrs	up	1.59	3.10e-12	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	1.84	5.76e-22	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_72h	up	2.01	4.19e-06	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	down	-1.98	5.64e-04	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000170345
Gene description:	Fos proto-oncogene, AP-1 transcription factor subunit
Chromosome:	14
Position	75278774-75282230
Protein class:	Cancer-related genes, Predicted intracellular proteins, Transcription factors
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm