HVIDB-PPI detail

P00973 (OAS1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: OAS1_HUMAN

UniProtID: P00973

Gene name(s): OAS1;OIAS

Protein name: 2'-5'-oligoadenylate synthase 1

Gene ID: 4938

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
P00973-P27958	biogrid,HPIDB	15893726	pull down

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.046).	Show
Machine learning evidence:	yes (score 0.059).

Combined Score: 0.185

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE67198	uninfected_control	1.5HA_u_per_mL_Sev_infected	up	1.73	8.44e-08	Microarray data
GSE100839	mock_infected	EBOV_infected	up	3.49	1.56e-29	RNA-Seq data
GSE101760	control_infected	PR8_infected	up	2.38	1.17e-02	RNA-Seq data
GSE101760	control_infected	PR8_NS1_infected	up	4.01	2.63e-14	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	3.74	1.79e-08	RNA-Seq data
GSE102481	mock_infected_9h	RVFV_MP12_infected_9h	up	2.49	6.98e-15	RNA-Seq data
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	1.68	3.38e-04	RNA-Seq data
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	3.46	1.51e-47	RNA-Seq data
GSE68673	A549_uninfected	A549_infected	up	2.07	7.09e-27	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	4.07	2.60e-159	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_8h	up	1.93	6.42e-26	RNA-Seq data
GSE82232	uninfected	infected_4h	up	2.67	2.56e-02	RNA-Seq data
GSE83525	B19_NS1_unexpressed	B19_NS1_expressed	up	3.25	4.70e-02	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	3.30	9.73e-13	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	2.71	1.09e-25	RNA-Seq data
GSE84346	uninfected_control	HCV_infected_high_ISG	up	2.15	9.27e-07	RNA-Seq data
GSE84897	MKN7_WT_control	MKN7_EBV_infected	up	2.87	2.38e-02	RNA-Seq data
GSE11348	2d_Postinfection_control	2d_Postinfection_RV16	up	1.61	1.23e-04	Microarray data
GSE13637	HUVEC_control	FPV-infected_HUVEC	up	3.04	2.36e-05	Microarray data
GSE13637	HUVEC_control	FPV-infected_IKK2kd-transfected_HUVEC	up	3.50	2.23e-06	Microarray data
GSE13637	HUVEC_control	FPV-infected_pEGZ-transfected_HUVEC	up	4.88	3.32e-08	Microarray data
GSE13637	HUVEC_control	H5N1-infected_HUVEC	up	4.19	1.96e-06	Microarray data
GSE13637	HUVEC_control	H5N1-infected_IKK2kd-transfected_HUVEC	up	3.17	2.68e-06	Microarray data
GSE13637	HUVEC_control	H5N1-infected_pEGZ-transfected_HUVEC	up	4.40	7.69e-08	Microarray data
GSE13637	HUVEC_control	PR8-infected_HUVEC	up	5.29	7.50e-08	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	4.91	2.29e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	5.64	3.55e-08	Microarray data
GSE14816	TB40E_mock	TB40E_TB	up	2.30	5.02e-03	Microarray data
GSE15810	hMSCs_mock-transduced	hMSCs_BV-transduced	up	6.44	2.98e-04	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	5.60	3.94e-05	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.97	5.00e-04	Microarray data
GSE30719	uninfected_primary_RPE	WNV_infected_primary_RPE_24h	up	4.82	2.61e-05	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	1.94	2.63e-02	Microarray data
GSE30723	AMs_control_4h	AMs_PR8_4h	up	1.96	9.84e-03	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	5.60	2.66e-05	Microarray data
GSE31193	control	IFN_24h	up	2.20	2.88e-06	Microarray data
GSE31193	control	IFN_6h	up	3.00	2.66e-08	Microarray data
GSE31193	control	IL2B_24h	up	3.32	2.49e-08	Microarray data
GSE31193	control	IL2B_6h	up	3.00	8.96e-08	Microarray data
GSE31518	A549_mock_infection	A549_pH1N1_infection_10h	up	2.43	2.82e-07	Microarray data
GSE31518	A549_mock_infection	A549_pH1N1_infection_8h	up	1.90	8.77e-07	Microarray data
GSE31524	H1N1_Mock_infection_10h	H1N1_infection_10h	up	2.53	8.58e-07	Microarray data
GSE31524	H5N2-F118_Mock_infection	H5N2-F118_infection_10h	up	3.56	2.84e-07	Microarray data
GSE31524	H5N2-F118_Mock_infection	H5N2-F118_infection_6h	up	2.87	1.23e-07	Microarray data
GSE31524	H5N2-F118_Mock_infection	H5N2-F118_infection_8h	up	3.33	2.71e-08	Microarray data
GSE59226	Control	Inactivate	up	5.39	4.82e-06	Microarray data
GSE31524	H5N2-F189_Mock_infection	H5N2-F189_infection_10h	up	2.75	3.96e-08	Microarray data
GSE31524	H5N2-F59_Mock_infection	H5N2-F59_infection_10h	up	3.04	3.40e-08	Microarray data
GSE31524	H5N3_Mock_infection	H5N3_infection_10h	up	1.70	3.43e-06	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_10h	up	3.73	5.47e-08	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_6h	up	2.37	1.84e-04	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_8h	up	3.33	2.16e-06	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	4.63	7.25e-08	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	4.62	2.34e-07	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	5.05	7.88e-05	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	4.56	3.49e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	5.26	1.03e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	5.79	2.18e-06	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	8.49	4.22e-06	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	9.02	1.21e-06	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-1.80	4.69e-04	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-1.96	2.84e-03	Microarray data
GSE38453	NA_mock_P1	NA_TS-MG_P10	down	-1.75	5.60e-04	Microarray data
GSE38900-GPL10558	healthy_matched_control	RSV_LRTI_infection	up	1.79	2.86e-03	Microarray data
GSE38900-GPL6884	Dallas_healthy_matched_control	Dallas_influenza_A_infection	up	2.11	4.33e-09	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	2.92	1.41e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Anhui01_pCalu3_12h	up	2.80	2.21e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_NL219_pCalu3_12h	up	2.87	1.80e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	3.99	3.90e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_VN1203_pCalu3_12h	up	2.46	1.04e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	2.82	3.64e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	3.46	2.05e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	4.86	1.98e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	3.34	5.03e-08	Microarray data
GSE53103	HeLa_no_infection	Hela_SV_12h	up	3.29	1.81e-08	Microarray data
GSE53103	HeLa_shmH2A1	HeLa_shmH2A1_+SV_6h	up	2.04	5.93e-03	Microarray data
GSE53103	HeLa_shscr	HeLa_shscr_+SV_6h	up	1.78	4.98e-05	Microarray data
GSE53103	Namalwa_no_infection	Namalwa_SV_6h	up	1.60	1.07e-06	Microarray data
GSE53103	Namalwa_shmH2A1	Namalwa_shmH2A1_+SV_6h	up	4.18	1.67e-02	Microarray data
GSE53543	uninfected_control	RV_infected	up	2.91	4.74e-116	Microarray data
GSE57647	Mock_infection_24h	JEV_infection_24h	up	4.32	3.94e-08	Microarray data
GSE57647	Mock_infection_48h	JEV_infection_48h	up	3.52	2.25e-04	Microarray data
GSE93385	K054_mock_infected	K054_ZIKV_infected	up	5.86	3.77e-58	RNA-Seq data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	8.90	4.73e-51	RNA-Seq data
GSE59226	Control	Virus_infection	up	3.18	9.13e-05	Microarray data
GSE97949	uninfected_0h	H7N9_infected_7h	up	2.94	3.75e-45	RNA-Seq data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-2.44	1.10e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.87	2.09e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	3.82	8.92e-05	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	3.00	1.38e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	3.53	3.29e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	4.64	2.79e-31	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	3.63	7.32e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.22	1.33e-02	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	3.41	5.80e-14	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	3.60	4.70e-15	Microarray data
GSE87750-GPL16791	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	up	8.44	1.11e-04	RNA-Seq data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	4.61	2.99e-04	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	4.35	4.34e-04	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_6h	HTBE_H1N1_MOI5_infected_6h	up	1.81	5.44e-14	RNA-Seq data
GSE67059-GPL10558	HRV-_healthy_control	HRV+_asymptomatic	up	2.02	1.98e-03	Microarray data
GSE67059-GPL6947	HRV-_healthy_control	HRV+_inpatients	up	1.87	2.44e-09	Microarray data
GSE67059-GPL6947	HRV-_healthy_control	HRV+_outpatients	up	1.54	7.57e-05	Microarray data
GSE87750-GPL16791	hPN_mock_infected	hPN_ZIKV-PRVABC59_infected	up	3.36	3.46e-02	RNA-Seq data
GSE71673	SK-N-SH_control_72h	Coxsackievirus_A16_72h	up	1.56	4.60e-02	Microarray data
GSE71766	BEAS-2B_control_12hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_12hrs	up	1.66	6.22e-05	Microarray data
GSE89008	HTBE_H3N2_MOI0_mock_infected_3h	HTBE_H3N2_MOI5_infected_3h	up	2.02	1.36e-14	RNA-Seq data
GSE71766	BEAS-2B_control_12hrs	BEAS-2B_InfluenzaVirus_12hrs	up	1.98	4.46e-06	Microarray data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_24hrs	up	5.04	7.68e-17	Microarray data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_InfluenzaVirus_24hrs	up	5.08	3.90e-17	Microarray data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_RhinoVirus_24hrs	up	2.29	2.30e-10	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	4.99	8.46e-216	RNA-Seq data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_36hrs	up	5.18	4.07e-16	Microarray data
GSE89008	HTBE_H3N2_MOI0_mock_infected_6h	HTBE_H3N2_MOI5_infected_6h	up	5.23	1.54e-123	RNA-Seq data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_InfluenzaVirus_36hrs	up	5.00	9.51e-16	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_6h	HTBE_H5N1_MOI5_infected_6h	up	2.18	1.67e-24	RNA-Seq data
GSE71766	BEAS-2B_control_36hrs	BEAS-2B_RhinoVirus_36hrs	up	3.92	1.35e-13	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	5.16	1.87e-14	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_InfluenzaVirus_48hrs	up	4.75	3.70e-14	Microarray data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_RhinoVirus_48hrs	up	4.91	3.27e-14	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	5.00	5.83e-191	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	5.91	8.26e-200	RNA-Seq data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_60hrs	up	4.44	4.58e-15	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	2.52	1.89e-34	RNA-Seq data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_InfluenzaVirus_60hrs	up	3.84	1.18e-14	Microarray data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_RhinoVirus_60hrs	up	4.82	1.42e-15	Microarray data
GSE71766	BEAS-2B_control_72hrs	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrs	up	3.94	2.99e-15	Microarray data
GSE71766	BEAS-2B_control_72hrs	BEAS-2B_InfluenzaVirus_72hrs	up	3.24	1.69e-14	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	2.16	2.84e-75	RNA-Seq data
GSE71766	BEAS-2B_control_72hrs	BEAS-2B_RhinoVirus_72hrs	up	4.06	1.66e-15	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	5.31	3.12e-127	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	6.28	9.84e-177	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_24hrs	up	4.65	2.29e-16	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	1.92	3.82e-13	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_36hrs	up	4.99	1.62e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_48hrs	up	4.92	9.97e-17	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_60hrs	up	4.51	8.69e-17	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrs	up	4.20	2.07e-16	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	1.87	2.26e-29	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_12hrs	up	1.74	7.95e-10	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	2.25	4.95e-43	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_24hrs	up	4.70	1.07e-16	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_03h	MDM-418_H3N2_MOI2_03h	up	2.66	1.03e-30	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_36hrs	up	4.80	1.49e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_48hrs	up	4.51	1.55e-16	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	2.54	1.04e-48	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_60hrs	up	3.92	6.72e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_72hrs	up	3.51	7.32e-16	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_24hrs	up	1.90	3.56e-10	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_36hrs	up	3.73	1.87e-14	Microarray data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	up	1.70	8.80e-23	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_48hrs	up	4.67	6.31e-17	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_60hrs	up	4.90	7.05e-17	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	up	4.32	1.45e-16	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	1.91	5.94e-18	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	1.64	3.49e-26	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	1.67	3.16e-22	RNA-Seq data
GSE73072	H3N2_DEE2_0h	H3N2_DEE2_77h	up	1.52	1.31e-02	Microarray data
GSE73072	H3N2_DEE2_-23h	H3N2_DEE2_77h	up	1.52	1.94e-02	Microarray data
GSE77087	healthy_control	RSV_inpatient	up	1.72	1.50e-07	Microarray data
GSE77087	healthy_control	RSV_outpatient	up	1.83	7.67e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_12h	up	3.23	2.47e-04	Microarray data
GSE8961	Mock_infection	HMPV_infection_24h	up	4.12	2.82e-07	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	4.06	1.18e-04	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	up	3.20	3.75e-06	Microarray data
GSE9378	HUVECs_mock-infected_control	HUVECs_DV_infection_48h	up	4.95	1.14e-03	Microarray data
GSE9378	Monocyte_mock-infected_control	Monocyte_DV_infection_48h	up	3.48	4.55e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	3.98	6.29e-03	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	3.60	8.20e-04	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_6h	up	3.36	7.24e-03	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	4.58	2.61e-15	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000089127
Gene description:	2'-5'-oligoadenylate synthetase 1
Chromosome:	12
Position	112906777-112933222
Protein class:	Enzymes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol