O96017 (CHEK2)

Homo sapiens

P27958-PRO_0000037577 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: CHK2_HUMAN

UniProtID: O96017

Gene name(s): CHEK2;CDS1;CHK2;RAD53

Protein name: Serine/threonine-protein kinase Chk2

Gene ID: 11200

HDF/HRF: NA

Virus protein: RNA-directed RNA polymerase(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037577

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
O96017-P27958-PRO_0000037577HPIDB18667510anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.657).
Combined Score: 0.998


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2236ASF1-histone containing complex70.14 (1/7)15664198CORUMView
227GALE-PGD-GSTO2-CHEK2-GPD1L-ISYNA1-ALDOA-ALDOC-PGP-ATP1B1100.10 (1/10)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE67198uninfected_control1.5HA_u_per_mL_Sev_infectedup1.991.15e-08Microarray data
GSE101760control_infectedPR8_NS1_infectedup2.213.17e-03RNA-Seq data
GSE101760mock_infectedPR8_NS1_infectedup1.914.89e-03RNA-Seq data
GSE102481mock_infected_18hRVFV_MP12_infected_18hup1.961.25e-17RNA-Seq data
GSE79968IMR90_GFP_32hIMR90_MCPyV_ST_32hup2.968.61e-04RNA-Seq data
GSE30589Vero_E6_Mock_infected_15hpiVero_E6_SARS-Cov_WT_15hpiup1.578.35e-05Microarray data
GSE30723AMs_control_4hAMs_PR8_4hup1.661.91e-02Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infecteddown-1.648.43e-05Microarray data
GSE50938extracted_total_RNA_mock-infected_NHDFsextracted_total_RNA_HCMV-infected_HNDFs_48h_post-infectiondown-1.836.73e-05Microarray data
GSE67198uninfected_control150HA_u_per_mL_Sev_infectedup2.395.70e-08Microarray data
GSE8961Mock_infectionHMPV_infection_24hup1.881.12e-04Microarray data
GSE8961Mock_infectionHMPV_infection_48hup2.471.86e-02Microarray data
GSE8961Mock_infectionHMPV_infection_72hup3.934.08e-06Microarray data

Human tissue specific expression (TPM)

Small intestine: 7.4 Liver: 2.8 Gallbladder: 7.0 Duodenum: 6.2 Rectum: 10.2 Tonsil: 10.1 Stomach: 3.3 Salivary glanda: 1.3 Adipose tissue: 3.9 Lung: 5.8 Lymph node: 11.6 Pancreas: 0.1 Kidney: 1.9 Colon: 8.2 Appendix: 10.3 Smooth musle: 7.1 Breast: 5.6 Parathyroid gland: 1.9 Esophagus: 5.4 Heart muscle: 0.8 Spleen: 6.4 Skeletal muscle: 0.3 Bone marrow: 9.0 Skin: 6.9 Urinary bladder: 6.7 Cervix, uterine: 4.9 Endometrium: 7.1 Ovary: 7.2 Fallopian tube: 4.6 Seminal vesicle: 4.8 Prostate: 3.7 Epididymis: 6.3 Testis: 13.4 Placenta: 10.4 Thyroid gland: 5.6 Cerebral cortex: 0.4 Adrenal gland: 7.0
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000183765
Gene description:Checkpoint kinase 2
Chromosome:22
Position28687743-28742422
Protein class:Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Golgi apparatus