Human protein: SRBS2_HUMAN
UniProtID: O94875
Gene name(s): SORBS2;ARGBP2;KIAA0777
Protein name: Sorbin and SH3 domain-containing protein 2
Gene ID: 8470
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| O94875-P27958 | biogrid,HPIDB | 18985028 | affinity chromatography technology |
| Interolog evidence: | none/insignificant. | |
| DDI evidence: | yes (score 0.022). | Show |
| Machine learning evidence: | yes (score 0.163). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 5709 | ArgBP2a-CBL-PTK2B complex | 3 | 0.33 (1/3) | 15128873 | CORUM | View |
| 254 | CART complex | 30 | 0.10 (3/30) | NA | hu.MAP | View |
| 780 | CART complex | 48 | 0.12 (6/48) | NA | hu.MAP | View |
| 1704 | Emerin complex 1 | 21 | 0.10 (2/21) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE100839 | mock_infected | EBOV_infected | down | -1.57 | 1.49e-07 | RNA-Seq data |
| GSE28166 | mock_infected_18h | VN1203_infected_18h | down | -2.31 | 6.83e-04 | Microarray data |
| GSE28166 | mock_infected_24h | VN1203_infected_24h | down | -3.06 | 5.57e-05 | Microarray data |
| GSE32155 | CRL-5800_unifected | CRL-1472_infected | up | 3.61 | 2.94e-05 | Microarray data |
| GSE32155 | CRL-5810_unifected | CRL-1472_infected | up | 3.87 | 1.45e-05 | Microarray data |
| GSE32155 | HTB-3_unifected | HTB-174_infected | down | -1.72 | 5.60e-03 | Microarray data |
| GSE32155 | HTB-4_unifected | HTB-174_infected | down | -3.87 | 6.34e-03 | Microarray data |
| GSE45042 | ELC001_mock_infected_24h | ECL001_EMC_infected_24h | down | -1.70 | 6.97e-05 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_Anhui01_pCalu3_24h | down | -2.26 | 5.96e-05 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_NL219_pCalu3_24h | down | -2.84 | 3.61e-05 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_Pan99_pCalu3_24h | down | -2.41 | 1.10e-04 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_VN1203_pCalu3_24h | down | -3.67 | 1.36e-05 | Microarray data |
| GSE99298 | mock_infected_0h | hRSV_WT_infected_96h | down | -3.92 | 1.53e-02 | RNA-Seq data |
| GSE68503 | empty_vector_control | tumor-derived_LT339+sT | down | -3.91 | 3.80e-02 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Tissue enhanced:
| Tissue | Expression (TPM) |
|---|---|
| heart muscle | 378.9 |
| thyroid gland | 462.8 |
| Ensembl ID: | ENSG00000154556 |
| Gene description: | Sorbin and SH3 domain containing 2 |
| Chromosome: | 4 |
| Position | 185585444-185956652 |
| Protein class: | Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleoplasm |