HVIDB-PPI detail

O94813 (SLIT2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: SLIT2_HUMAN

UniProtID: O94813

Gene name(s): SLIT2;SLIL3

Protein name: Slit homolog 2 protein

Gene ID: 9353

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
O94813-P27958	biogrid,HPIDB	18985028	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.021).	Show
Machine learning evidence:	yes (score 0.192).

Combined Score: 0.419

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
3351	CHPF2-TXNDC16-SIAE-CHID1-FUT11-PCSK6-CHPF-TMEM132A-PRCP-MAN2B1-MAN2A1-BMP7-GALNT18-FOXRED2-SLIT2-PAM-IL17RA-PLTP-GALNS-MEGF8-B3GLCT-EDEM3-SGSH-HYAL2-NID1-PLXNA1-KDELC1-NAGLU-GUSB-CERCAM-ARSA-UGGT2-COL18A1	33	0.03 (1/33)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	4.40	1.97e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	4.85	1.54e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-3.26	4.74e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	down	-2.81	9.32e-05	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-8.66	1.19e-07	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-9.33	4.02e-07	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	up	1.95	3.66e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	down	-1.52	1.46e-03	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.53	1.49e-04	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.88	4.82e-04	Microarray data
GSE59226	Control	Virus_infection	down	-2.79	1.03e-04	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	4.36	3.61e-04	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	1.67	1.15e-05	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	3.16	2.47e-16	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	3.27	5.63e-03	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	4.14	1.94e-02	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	4.59	7.58e-03	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	up	6.70	8.37e-11	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	up	4.13	2.88e-02	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	4.99	1.56e-03	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	5.35	2.01e-15	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	6.58	4.25e-25	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	6.13	3.44e-17	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	6.30	7.48e-09	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000145147
Gene description:	Slit guidance ligand 2
Chromosome:	4
Position	20253260-20620561
Protein class:	Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Evidence:	Evidence at protein level
Subcellular location: