O76003 (GLRX3)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: GLRX3_HUMAN

UniProtID: O76003

Gene name(s): GLRX3;PICOT;TXNL2;HUSSY-22

Protein name: Glutaredoxin-3

Gene ID: 10539

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
O76003-P27958-PRO_0000037566HPIDB15846844pull down

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.631). Show
DDI evidence: yes (score 0.016). Show
Machine learning evidence: yes (score 0.733).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
6958BOLA2-GLRX3 complex20.50 (1/2)22309771CORUMView
2543APPBP1-UBA3 complex30.33 (1/3)NAhu.MAPView
3763HYKK-C14orf142-GLRX3-OSGEP-TPRKB-TP53RK-MFAP3-LAGE380.12 (1/8)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE65123healthy_seronegative_controlHCV_infecteddown-4.414.28e-02Microarray data

Human tissue specific expression (TPM)

Small intestine: 35.3 Liver: 22.2 Gallbladder: 45.9 Duodenum: 36.7 Rectum: 43.6 Tonsil: 58.1 Stomach: 31.7 Salivary glanda: 13.9 Adipose tissue: 42.2 Lung: 37.6 Lymph node: 64.5 Pancreas: 7.6 Kidney: 39.8 Colon: 33.0 Appendix: 55.8 Smooth musle: 60.3 Breast: 44.4 Parathyroid gland: 44.2 Esophagus: 54.7 Heart muscle: 33.5 Spleen: 37.9 Skeletal muscle: 16.8 Bone marrow: 23.6 Skin: 49.9 Urinary bladder: 44.9 Cervix, uterine: 39.9 Endometrium: 50.0 Ovary: 30.1 Fallopian tube: 41.6 Seminal vesicle: 41.7 Prostate: 44.6 Epididymis: 35.2 Testis: 119.3 Placenta: 59.6 Thyroid gland: 55.4 Cerebral cortex: 44.4 Adrenal gland: 53.1
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000108010
Gene description:Glutaredoxin 3
Chromosome:10
Position130136399-130184521
Protein class:Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location: