HVIDB-PPI detail

O60603 (TLR2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: TLR2_HUMAN

UniProtID: O60603

Gene name(s): TLR2;TIL4

Protein name: Toll-like receptor 2

Gene ID: 7097

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
O60603-P27958	PHISTO	15521019	confocal microscopy

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.039).

Combined Score: 0.023

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
7048	TLR1-TLR2 complex	2	0.50 (1/2)	17889651	CORUM	View
7049	TLR1-TLR2-lipoprotein complex	2	0.50 (1/2)	23430250	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	2.88	5.91e-16	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	2.38	4.40e-05	RNA-Seq data
GSE15810	hMSCs_mock-transduced	hMSCs_BV-transduced	up	2.64	2.20e-03	Microarray data
GSE19345	Mock_infected	HCMV_infected_24h	up	1.90	5.16e-05	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-2.75	1.80e-02	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-2.07	9.37e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-3.97	4.90e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-5.24	2.78e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	2.29	1.42e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	3.25	3.24e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	4.40	3.75e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	4.18	1.55e-04	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	up	3.32	5.31e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-1.58	1.95e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-3.37	1.96e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-2.62	1.40e-05	Microarray data
GSE58914	NOK_cl1_uninfected	NOK_cl1_AkataBX-1_cl1_EBV-	down	-1.61	3.18e-03	Microarray data
GSE58914	NOK_cl1_uninfected	NOK_cl1_AkataBX-1_cl3_EBV-	down	-1.66	2.21e-03	Microarray data
GSE58914	NOK_cl1_uninfected	NOK_cl1_AkataBX-1_cl4_EBV+	down	-1.76	1.48e-03	Microarray data
GSE59226	Control	Virus_infection	down	-2.81	1.60e-03	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	2.27	1.05e-02	Microarray data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	2.08	2.99e-05	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	1.72	2.77e-03	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
appendix	52.7

Ensembl ID:	ENSG00000137462
Gene description:	Toll like receptor 2
Chromosome:	4
Position	153701500-153705699
Protein class:	CD markers, FDA approved drug targets, Predicted membrane proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Mitochondria