O60488 (ACSL4)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: ACSL4_HUMAN

UniProtID: O60488

Gene name(s): ACSL4;ACS4;FACL4;LACS4

Protein name: Long-chain-fatty-acid--CoA ligase 4

Gene ID: 2182

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
O60488-P27958PHISTO22911572confocal microscopy

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.107).
Combined Score: 0.068


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
643ACSS2-ACSL4-GALK2-MVD40.25 (1/4)NAhu.MAPView
1413TUBA1B-ACSL4-ABCF2-EIF2S3-CAD50.20 (1/5)NAhu.MAPView
1946ACSL4-MVD20.50 (1/2)NAhu.MAPView
2112TUBA1B-ACSL4-ABCF2-EIF2S340.25 (1/4)NAhu.MAPView
4436ACSS2-ACSL4-MVD30.33 (1/3)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE84346uninfected_controlHCV_infected_high_ISGup3.613.33e-05RNA-Seq data
GSE27702control_macrophagesFPV-infected_macrophagesdown-1.771.27e-02Microarray data
GSE28166mock_infected_18hVN1203_infected_18hdown-2.337.98e-04Microarray data
GSE28166mock_infected_24hVN1203_infected_24hdown-2.853.87e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_Anhui01_pCalu3_24hdown-2.284.51e-08Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-1.932.32e-05Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hup2.121.60e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-1.601.55e-02Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hdown-1.683.60e-02Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.701.33e-02Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup1.651.75e-03Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hup1.973.79e-02Microarray data
GSE89008HTBE_H5N1_MOI0_mock_infected_12hHTBE_H5N1_MOI5_infected_12hdown-1.892.09e-13RNA-Seq data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-2.339.83e-24RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-1.838.06e-04RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hdown-1.584.94e-32RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-2.537.94e-56RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-2.885.67e-67RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-2.725.35e-74RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hdown-2.145.78e-50RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 14.6 Liver: 7.1 Gallbladder: 45.2 Duodenum: 14.6 Rectum: 14.8 Tonsil: 16.3 Stomach: 17.9 Salivary glanda: 3.7 Adipose tissue: 50.1 Lung: 57.5 Lymph node: 26.9 Pancreas: 2.6 Kidney: 47.2 Colon: 12.6 Appendix: 53.0 Smooth musle: 32.0 Breast: 18.7 Parathyroid gland: 36.6 Esophagus: 17.4 Heart muscle: 19.1 Spleen: 29.4 Skeletal muscle: 3.9 Bone marrow: 9.6 Skin: 9.4 Urinary bladder: 33.5 Cervix, uterine: 70.7 Endometrium: 31.9 Ovary: 18.5 Fallopian tube: 21.9 Seminal vesicle: 20.5 Prostate: 21.4 Epididymis: 19.4 Testis: 49.7 Placenta: 30.0 Thyroid gland: 30.3 Cerebral cortex: 51.8 Adrenal gland: 51.3
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000068366
Gene description:Acyl-CoA synthetase long-chain family member 4
Chromosome:X
Position109624244-109733403
Protein class:Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Evidence:Evidence at protein level
Subcellular location:Golgi apparatus, Mitochondria