Human protein: PRKN_HUMAN
UniProtID: O60260
Gene name(s): PRKN;PARK2
Protein name: E3 ubiquitin-protein ligase parkin
Gene ID: 5071
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| O60260-P27958 | biogrid,HPIDB | 25244949 | two hybrid |
| Interolog evidence: | none/insignificant. | |
| DDI evidence: | yes (score 0.025). | Show |
| Machine learning evidence: | yes (score 0.113). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 5423 | HSP70-BAG5-PARK2 complex | 4 | 0.50 (2/4) | 15603737 | CORUM | View |
| 5837 | PPD complex | 3 | 0.33 (1/3) | 19229105 | CORUM | View |
| 6036 | PARK2-EPS15-EGFR complex | 3 | 0.33 (1/3) | 16862145 | CORUM | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE97949 | uninfected_0h | H7N9_infected_7h | down | -5.75 | 4.17e-02 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-520_H5N1_MOI0_18h | MDM-520_H5N1_MOI2_18h | down | -2.39 | 8.67e-03 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000185345 |
| Gene description: | Parkin RBR E3 ubiquitin protein ligase |
| Chromosome: | 6 |
| Position | 161347420-162727771 |
| Protein class: | Disease related genes, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nuclear speckles, Cytosol |