HVIDB-PPI detail

O15105 (SMAD7)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: SMAD7_HUMAN

UniProtID: O15105

Gene name(s): SMAD7;MADH7;MADH8

Protein name: Mothers against decapentaplegic homolog 7

Gene ID: 4092

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
O15105-P27958	biogrid,HPIDB	23781096	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.031).

Combined Score: 0.020

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1777	Ubiquitin E3 ligase (SMURF2, SMAD7) - TGF(beta)	4	0.50 (2/4)	11163210	CORUM	View
1783	Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR1	3	0.67 (2/3)	11278251	CORUM	View
2992	Ubiquitin E3 ligase (SMAD7, SMURF2)	2	1.00 (2/2)	11163210	CORUM	View
2996	Ubiquitin E3 ligase (SMAD7, SMURF1)	2	1.00 (2/2)	11278251	CORUM	View
2997	Ubiquitin E3 ligase (SMAD7-SMURF1) - TGF(beta)	4	0.50 (2/4)	11278251	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE13637	HUVEC_control	FPV-infected_HUVEC	down	-2.35	2.64e-04	Microarray data
GSE13637	HUVEC_control	H5N1-infected_HUVEC	down	-1.75	1.71e-04	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-3.33	5.27e-03	Microarray data
GSE27702	control_macrophages	H5N1-infected_macrophages	down	-3.22	3.96e-03	Microarray data
GSE31524	H5N2-F118_Mock_infection	H5N2-F118_infection_10h	down	-2.17	2.02e-04	Microarray data
GSE31524	H5N2-F59_Mock_infection	H5N2-F59_infection_10h	down	-1.52	3.07e-06	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	2.06	1.23e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	2.88	1.54e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	1.63	2.80e-03	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.76	6.70e-05	Microarray data
GSE43794	NPCs_jCV_infection_0h	NPCs_jCV_infection_30d	up	1.75	9.78e-07	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	up	2.10	1.12e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	down	-2.09	5.24e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	2.03	2.58e-07	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-1.56	6.24e-05	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.02	1.30e-03	Microarray data
GSE59226	Control	Virus_infection	down	-2.08	1.65e-04	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-2.23	2.53e-02	Microarray data
GSE97949	uninfected_0h	H7N9_infected_3h	down	-1.86	2.40e-04	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	2.80	1.71e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	3.76	1.08e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	3.48	1.77e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	4.68	6.10e-03	Microarray data
GSE68503	empty_vector_control	tumor-derived_LT339+sT	down	-2.09	9.22e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_6h	HTBE_H5N1_MOI5_infected_6h	down	-1.57	1.40e-05	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-2.20	1.84e-24	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-3.97	1.66e-67	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-3.03	3.99e-51	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.66	2.23e-16	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-1.87	1.56e-16	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000101665
Gene description:	SMAD family member 7
Chromosome:	18
Position	48919853-48950711
Protein class:	Disease related genes, Predicted intracellular proteins, Transcription factors
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm, Cytosol