O14920 (IKBKB)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: IKKB_HUMAN

UniProtID: O14920

Gene name(s): IKBKB;IKKB

Protein name: Inhibitor of nuclear factor kappa-B kinase subunit beta

Gene ID: 3551

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
O14920-P27958biogrid,HPIDB15919917affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.004). Show
Machine learning evidence: yes (score 0.142).
Combined Score: 0.133


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2055CASP8-CHUK-IKBKB-MALT1-BCL10 complex50.20 (1/5)15746428CORUMView
2100CHUK-IKBKB-MAP3K14 complex30.33 (1/3)9346485CORUMView
2101IKKA-IKKB complex20.50 (1/2)9346485CORUMView
2104IKKB-NIK complex20.50 (1/2)9346485CORUMView
2105IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14)60.17 (1/6)9751059CORUMView
2118CHUK-ERC1-IKBKB-IKBKG40.50 (2/4)15218148CORUMView
2121I-kappa-B kinase complex30.33 (1/3)9751060CORUMView
2727SRC-3 complex70.29 (2/7)11971985CORUMView
5194TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2)100.20 (2/10)14743216CORUMView
5233TNF-alpha/NF-kappa B signaling complex 5250.08 (2/25)14743216CORUMView
5234IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex50.60 (3/5)14743216CORUMView
5266TNF-alpha/NF-kappa B signaling complex 6140.36 (5/14)14743216CORUMView
5828IKBKG-IKBKB complex20.50 (1/2)12612076CORUMView
5844I-kappa-B kinase complex30.33 (1/3)10893415CORUMView
6344TNF-R1-associated signaling complex150.33 (5/15)20005846CORUMView
2038IKBKG-IKBKB complex20.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE13637HUVEC_controlH5N1-infected_IKK2kd-transfected_HUVECup1.764.14e-05Microarray data
GSE32155HTB-3_unifectedHTB-174_infectedup2.213.78e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-1.595.94e-07Microarray data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-2.342.28e-06RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-1.621.66e-02RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-2.311.07e-25RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-2.261.52e-18RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-2.462.64e-21RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hdown-2.051.41e-16RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 2.8 Liver: 3.1 Gallbladder: 14.2 Duodenum: 3.0 Rectum: 7.8 Tonsil: 10.3 Stomach: 4.8 Salivary glanda: 2.8 Adipose tissue: 7.1 Lung: 15.2 Lymph node: 10.4 Pancreas: 0.5 Kidney: 5.8 Colon: 5.7 Appendix: 4.4 Smooth musle: 16.0 Breast: 8.1 Parathyroid gland: 18.7 Esophagus: 12.2 Heart muscle: 3.0 Spleen: 10.9 Skeletal muscle: 3.0 Bone marrow: 4.5 Skin: 18.2 Urinary bladder: 14.6 Cervix, uterine: 8.6 Endometrium: 12.0 Ovary: 6.7 Fallopian tube: 17.4 Seminal vesicle: 8.4 Prostate: 8.0 Epididymis: 10.2 Testis: 3.8 Placenta: 10.9 Thyroid gland: 15.8 Cerebral cortex: 5.8 Adrenal gland: 5.1
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000104365
Gene description:Inhibitor of nuclear factor kappa B kinase subunit beta
Chromosome:8
Position42271302-42332653
Protein class:Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Evidence:Evidence at protein level
Subcellular location:Cytosol