O14576 (DYNC1I1)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: DC1I1_HUMAN

UniProtID: O14576

Gene name(s): DYNC1I1;DNCI1;DNCIC1

Protein name: Cytoplasmic dynein 1 intermediate chain 1

Gene ID: 1780

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
O14576-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.006). Show
Machine learning evidence: yes (score 0.754).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
6038Dynein complex40.25 (1/4)17403682CORUMView
6039Dynein-dynactin complex50.20 (1/5)17403682CORUMView
6960BICD2-dynein-dynactin complex30.33 (1/3)28883039CORUMView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE68673A549_uninfectedA549_infectedup7.083.49e-03RNA-Seq data
GSE75699HNBE_control_0hHNBE_infected_24hup1.832.72e-03RNA-Seq data
GSE32155CRL-5800_unifectedCRL-5807_infectedup7.815.69e-06Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infectedup7.498.14e-06Microarray data
GSE40711mock_infected_6hIDN3006_or_cl2PA_infected_6hdown-2.317.81e-04Microarray data
GSE45042ELC001_mock_infected_24hECL001_EMC_infected_24hup1.861.22e-04Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infecteddown-1.931.54e-03Microarray data
GSE65123healthy_seronegative_controlHCV_infectedup2.604.48e-02Microarray data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-2.062.85e-02RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 1.3 Liver: 0.1 Gallbladder: 3.1 Duodenum: 1.4 Rectum: 3.4 Tonsil: 0.5 Stomach: 1.3 Salivary glanda: 0.5 Adipose tissue: 1.9 Lung: 1.4 Lymph node: 1.0 Pancreas: 0.4 Kidney: 2.2 Colon: 2.2 Appendix: 2.1 Smooth musle: 5.1 Breast: 2.5 Parathyroid gland: 1.0 Esophagus: 3.8 Heart muscle: 12.0 Spleen: 1.9 Skeletal muscle: 1.0 Bone marrow: 0.7 Skin: 2.9 Urinary bladder: 5.3 Cervix, uterine: 2.3 Endometrium: 3.7 Ovary: 9.6 Fallopian tube: 1.9 Seminal vesicle: 11.5 Prostate: 12.3 Epididymis: 6.1 Testis: 4.6 Placenta: 1.2 Thyroid gland: 3.4 Cerebral cortex: 83.9 Adrenal gland: 16.8
Expression value is measured by Transcripts Per Million (TPM)
Tissue enhanced:
TissueExpression (TPM)
cerebral cortex 83.9
Ensembl ID:ENSG00000158560
Gene description:Dynein cytoplasmic 1 intermediate chain 1
Chromosome:7
Position95772506-96110322
Protein class:Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location: