Human protein: DDX3X_HUMAN
UniProtID: O00571
Gene name(s): DDX3X;DBX;DDX3
Protein name: ATP-dependent RNA helicase DDX3X
Gene ID: 1654
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| O00571-P27958 | PHISTO,biogrid,HPIDB | 17108031,20862261 | anti tag coimmunoprecipitation,affinity chromatography technology |
| Interolog evidence: | yes (score 0.973). | Show |
| DDI evidence: | none/insignificant. | |
| Machine learning evidence: | yes (score 0.251). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 1332 | Large Drosha complex | 20 | 0.15 (3/20) | 15531877 | CORUM | View |
| 351 | Spliceosome | 143 | 0.04 (6/143) | 12226669 | CORUM | View |
| 5232 | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) | 17 | 0.18 (3/17) | 14743216 | CORUM | View |
| 491 | Spliceosome | 46 | 0.07 (3/46) | NA | hu.MAP | View |
| 1516 | Large Drosha complex | 5 | 0.20 (1/5) | NA | hu.MAP | View |
| 1769 | Large Drosha complex | 3 | 0.33 (1/3) | NA | hu.MAP | View |
| 2933 | Large Drosha complex | 2 | 0.50 (1/2) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE102481 | mock_infected_18h | RVFV_MP12_infected_18h | up | 1.50 | 1.29e-10 | RNA-Seq data |
| GSE28166 | mock_infected_24h | VN1203_infected_24h | up | 1.80 | 8.43e-05 | Microarray data |
| GSE46041 | iPS-derived_neurons_uninfected | iPS-derived_neurons_HSV-1-infected | up | 2.05 | 2.08e-03 | Microarray data |
| GSE59226 | Control | Virus_infection | up | 1.76 | 2.11e-04 | Microarray data |
| GSE65574 | MCL001_mock_12h | MCL001_RFP-MERS_12h | down | -1.58 | 2.63e-02 | Microarray data |
| GSE65574 | MCL001_mock_24h | MCL001_d3-5-MERS_24h | up | 4.47 | 1.57e-04 | Microarray data |
| GSE65574 | MCL001_mock_24h | MCL001_d4B-MERS_24h | up | 4.90 | 1.09e-02 | Microarray data |
| GSE97672-GPL16791 | MDM-520_H5N1_MOI0_12h | MDM-520_H5N1_MOI2_12h | up | 1.50 | 5.48e-22 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000215301 |
| Gene description: | DEAD-box helicase 3, X-linked |
| Chromosome: | X |
| Position | 41333348-41364472 |
| Protein class: | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleus, Cytosol |