HVIDB-PPI detail

O00499-7 (BIN1)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: BIN1_HUMAN

UniProtID: O00499-7

Gene name(s): BIN1;AMPHL

Protein name: Myc box-dependent-interacting protein 1

Gene ID: 274

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
O00499-7-P27958-PRO_0000037576	HPIDB	12604805	anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.964).	Show
DDI evidence:	yes (score 0.012).	Show
Machine learning evidence:	yes (score 0.578).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
7281	BIN1-EHBP1-RAB8A complex	3	0.33 (1/3)	26833786	CORUM	View
1252	BIN1-DHX38	2	0.50 (1/2)	NA	hu.MAP	View
3205	BIN1-ADD1	2	0.50 (1/2)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-2.81	4.63e-02	RNA-Seq data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-2.11	4.17e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	2.49	3.14e-05	Microarray data
GSE59226	Control	Virus_infection	down	-1.67	3.44e-04	Microarray data
GSE65574	MCL001_mock_0h	MCL001_d4B-MERS_0h	down	-1.99	3.82e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_dNSP16-MERS_0h	down	-1.52	2.21e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-3.22	6.89e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.18	1.52e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.41	5.69e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_dNSP16-MERS_12h	down	-1.77	3.37e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-2.25	3.52e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.33	5.76e-04	Microarray data
GSE65574	MCL001_mock_7h	MCL001_icMERS_7h	down	-1.65	1.19e-02	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-2.33	1.65e-03	Microarray data
GSE67198	uninfected_control	150HA_u_per_mL_Sev_infected	up	2.54	1.07e-08	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.83	7.35e-09	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.44	2.34e-08	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.16	8.29e-13	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.63	6.12e-19	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-2.17	6.89e-24	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.17	2.37e-10	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Group enriched:

Tissue	Expression (TPM)
cerebral cortex	156.4
skeletal muscle	724.1

Ensembl ID:	ENSG00000136717
Gene description:	Bridging integrator 1
Chromosome:	2
Position	127048027-127107355
Protein class:	Disease related genes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol