| Introduction |
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Here, we introduce a comprehensive human-virus PPI database, HVIDB (http://zzdlab.com/hvidb/), which is based on (i) multiple data resources associated with human-virus PPIs and provides (ii) an integrative, computational platform to predict interactions between human and virus proteins.
Currently, HVIDB highlights 48,643 experimentally verified human-virus PPIs covering 35 virus families, 6,633 virally targeted host complexes, 3,572 host dependency/restriction factors as well as 911 experimentally verified/predicted 3D complex structures of human-virus PPIs. Furthermore, our database resource provides tissue-specific expression atlas for 6,790 human genes that are targeted by viruses and 129 GEO series of differentially expressed genes post viral infections.
| Data summary | Updated 25 June 2020 |
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| Human-virus PPIs | 48,643 |
| Viral families | 35 |
| 3D complex structures | 911 |
| GEO series of DEGs post viral infection (RNA-Seq) | 34 series (121 control-infection groups) |
| GEO series of DEGs post viral infection (Microarray) | 95 series (411 control-infection groups) |
| Human tissue-specific expression atlas | 6,790 |
| Virally targeted human complexes | 6,633 |
| Host factors | 3,572 |
| GO enrichments | 600 viral targeted human protein lists |
| KEGG enrichments | 604 viral targeted human protein lists |
Highlights
Experimentally verified human-virus PPIs
Interaction complexes
Virally targeted human complexes
Differentially expressed genes post viral infection
Tissue specific expression
Human-virus PPI prediction platform
| Citation | Yang X, Lian X, Fu C, Wuchty S, Yang S, Zhang Z. (2021) HVIDB: a comprehensive database for human-virus protein-protein interactions. Briefings in Bioinformatics 22:832-844. doi: 10.1093/bib/bbaa425 |
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