Here, we introduce a comprehensive human-virus PPI database, HVIDB (http://zzdlab.com/hvidb/), which is based on (i) multiple data resources associated with human-virus PPIs and provides (ii) an integrative, computational platform to predict interactions between human and virus proteins.
Currently, HVIDB highlights 48,643 experimentally verified human-virus PPIs covering 35 virus families, 6,633 virally targeted host complexes, 3,572 host dependency/restriction factors as well as 911 experimentally verified/predicted 3D complex structures of human-virus PPIs. Furthermore, our database resource provides tissue-specific expression atlas for 6,790 human genes that are targeted by viruses and 129 GEO series of differentially expressed genes post viral infections.
|Data summary||Updated 25 June 2020|
|3D complex structures||911|
|GEO series of DEGs post viral infection (RNA-Seq)||34 series (121 control-infection groups)|
|GEO series of DEGs post viral infection (Microarray)||95 series (411 control-infection groups)|
|Human tissue-specific expression atlas||6,790|
|Virally targeted human complexes||6,633|
|GO enrichments||600 viral targeted human protein lists|
|KEGG enrichments||604 viral targeted human protein lists|
Experimentally verified human-virus PPIs
Virally targeted human complexes
Differentially expressed genes post viral infection
Tissue specific expression
Human-virus PPI prediction platform
|Citation||Yang X, Lian X, Fu C, Wuchty S, Yang S, Zhang Z. (2021) HVIDB: a comprehensive database for human-virus protein-protein interactions. Briefings in Bioinformatics 22:832-844. doi: 10.1093/bib/bbaa425|