gene detail

Gene description

Short description: Similar to Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplast precursor (AK-HD 2) (AK-HSDH 2) [Includes: Aspartokinase (EC 2.7.2.4); Homoserine dehydrogenase (EC 1.1.1.3)].

Orthologous

Arabidopsis: No orthologous

Maize:

GRMZM2G104546

Wheat: No orthologous

GO biological process

cellular amino acid metabolic process (GO:0006520), metabolic process (GO:0008152), cellular amino acid biosynthetic process (GO:0008652), aspartate family amino acid biosynthetic process (GO:0009067), oxidation-reduction process (GO:0055114)

GO cellular component

unknown

GO molecular function

nucleotide binding (GO:0000166), aspartate kinase activity (GO:0004072), homoserine dehydrogenase activity (GO:0004412), oxidoreductase activity (GO:0016491), amino acid binding (GO:0016597), NADP binding (GO:0050661)

Protein domain

Pfam	PF00696, Amino acid kinase family
Pfam	PF03447, Homoserine dehydrogenase, NAD binding domain
Pfam	PF13840, ACT domain
Pfam	PF00742, Homoserine dehydrogenase

Metabolic pathway

PWY-3001: isoleucine biosynthesis I
PWY-724: superpathway of lysine, threonine and methionine biosynthesis II
THRESYN-PWY: threonine biosynthesis
PWY-5097: lysine biosynthesis VI
HOMOSERSYN-PWY: homoserine biosynthesis

KEGG pathway

PATH:dosa01230: Biosynthesis of amino acids
PATH:dosa00260: Glycine, serine and threonine metabolism
PATH:dosa00270: Cysteine and methionine metabolism
PATH:dosa00300: Lysine biosynthesis
PATH:dosa00261: Monobactam biosynthesis

Coexpression network

GSE62895_S_15B_ROOT  view
GSE63047_T7174R  view
GSE33411_IRBB5  view
GSE16793_XOO  view
GSE16793_XOC  view
GSE62894_S_77  view
GSE33411_IRBB7  view
GSE62895_R_15B_ROOT  view
GSE63047_DELTAHRCV  view
GSE33411_IR24  view

Differentially expressed condition

15 conditions

Series	Control	Treatment	Log₂FC	Adj. P value
GSE19239	Japonica 9804, Rxo1, control	Japonica 9804, Rxo1, X. oryzae pv. oryzicola	-2.76	1.65E-08
GSE33411	IR24, control	IR24, Xanthomonas oryzae pv. oryzae 12 h	-3.53	7.69E-14
GSE33411	IRBB5, control	IRBB5, Xanthomonas oryzae pv. oryzae 12 h	-3.86	8.81E-15
GSE33411	IRBB7, control	IRBB7, Xanthomonas oryzae pv. oryzae 12 h	-3.57	5.91E-14
GSE36272	IR24, MOCK	IR24, Xanthomonas oryzae strain PXO86	-1.66	5.92E-03
GSE36272	IR24, MOCK	IR24, Xanthomonas oryzae strain _PXO99A	-2.79	4.59E-06
GSE36272	IR24, MOCK	IR24, Xanthomonas oryzae strain PXO99AME1	-2.30	1.45E-04
GSE36272	IR24, MOCK	IR24, Xanthomonas oryzae strain PXO99AME5	-2.06	3.75E-04
GSE36272	IR24, MOCK	IR24, Xanthomonas oryzae strain PXO99A_2	-2.60	1.54E-05
GSE36272	Nipponbare, MOCK	Nipponbare, Xanthomonas oryzae strain T7174	-1.95	9.84E-04
GSE62894	Nipponbare, pish, water 5 d	Nipponbare, pish, Magnaporthe oryzae Kyu77-07A 5 d	-2.56	2.13E-03
GSE62895	Nipponbare, Pia, water 3 d	Nipponbare, Pia, Magnaporthe oryzae P91-15B 3 d	-2.50	2.88E-02
GSE62895	Nipponbare, pia, water 3 d	Nipponbare, pia, Magnaporthe oryzae P91-15B 3 d	-2.52	2.69E-02
GSE63047	Nipponbare, water 7 d	Nipponbare, Xanthomonas oryzae T7174R 7 d	-3.30	8.42E-13
GSE63337	Nipponbare, Osaba1_1, Xanthomonas oryzae pv. Oryzae PXO99 0 h	Nipponbare, Osaba1_1, Xanthomonas oryzae pv. Oryzae PXO99 72 h	-1.59	9.39E-03