JobID: E4Z2D1450339800 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = sp_Q64LD2_WDR25_HUMAN (Len=544)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (sp_Q64LD2_WDR25_HUMAN, Len=544):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKAGAQPTKHGSCEDPGGYRLPL 80  
WD40-rpts                              (_________________WD 1________________)                 

Query       81 AQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTSHVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKN 160 
WD40-rpts                                                                                   (__

Query      161 GSSFQKKKCEDCVVPYTPRRLRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240 
WD40-rpts      _______________WD 2________________)                                       (____

Query      241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTD 320 
WD40-rpts      ______________WD 3__________________)    (_________________WD 4________________)

Query      321 LETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTR 400 
WD40-rpts         (_________________WD 5________________)   (____________________WD 6__________

Query      401 DSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 
WD40-rpts      __________)   (_________________WD 7_________________)      (__________________W

Query      481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIWH 544 
WD40-rpts      D 8_________________)   (_________________WD 9_________________)

9 WD40-repeats found in QUERY=sp_Q64LD2_WDR25_HUMAN (Len=544):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg  3    25-63       5.72  351.00  0.00116       17.5%     -18.86
  WD 2:  Seg  4   158-196      5.35  335.60  0.00187       17.5%      9.45
  WD 3:  Seg  7   236-277      7.37  419.04  0.00014       35.0%     53.80
  WD 4:  Seg 11   282-320      9.90  523.81  5.4e-06       37.5%     58.08
  WD 5:  Seg 15   324-362      6.20  370.67  0.00063       25.0%     56.59
  WD 6:  Seg 19   366-411      7.65  430.47  9.8e-05       27.5%     51.46
  WD 7:  Seg 23   415-454      6.30  374.77  0.00055        7.5%     54.14
  WD 8:  Seg 27   461-501      7.62  429.62  0.00010       35.0%     52.09
  WD 9:  Seg 31   505-544      7.70  432.73  9.2e-05       27.5%     52.89

Multiple sequence alignment of 9 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1   25-63     EHAGSFNATGQQ-KDTSGV--ARP---P-GQDFASG-------TLDVPKAGAQ
   WD 2  158-196    GKNGSSFQKKKC-EDCVVP--YTP---R-RLRQRQA-------LSTETGKGKD
   WD 3  236-277    RKVLFHLRGHRG-PVNTIQ--WCPVLSK-SHMLLST-------SMDKTFKVWN
   WD 4  282-320    GHCLQTYSLHTE-AVRAAR--WAP---C-GRRILSG-------GFDFALHLTD
   WD 5  324-362    GTQLFSGRSDFR--ITTLK--FHP--KD-HNIFLCG-------GFSSEMKAWD
   WD 6  366-411    GKVMRSYKATIQ-QTLDIL--FLR---E-GSEFLSSTDASTRDSADRTIIAWD
   WD 7  415-454    SAKISNQIFHERFTCPSLA--LHP---R-EPVFLAQ-------TNGNYLALFS
   WD 8  461-501    MSRRRRYEGHKV-EGYSVGCECSP---G-GDLLVTG-------SADGRVLMYS
   WD 9  505-544    ASRACTLQGHTQ-ACVGTT--YHP---VLPSVLATC-------SWGGDMKIWH

   WD40 Template    GECLRTLSGHTS-GVTSVS--FSP---D-GKRLVSG-------SEDGTIKVWD