JobID: 9J6HS1620966760 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = 2AQ5_A_PDBID_CHAIN_SEQUENCE (Len=429)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (2AQ5_A_PDBID_CHAIN_SEQUENCE, Len=429):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGH 80  
WD40-rpts                      (_____________________WD 1____________________)(________________

Query       81 TAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWD 160 
WD40-rpts      _____WD 2____________________)          (_________________WD 3_________________)

Query      161 VGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFS 240 
WD40-rpts         (__________________WD 4_________________)   (___________________WD 5_________

Query      241 RMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMG 320 
WD40-rpts      __________)(____________________WD 6___________________)(____________________WD 

Query      321 YMPKRGLEVNKCEIARFYKLHERKCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPK 400 
WD40-rpts      7____________________)                                                          

Query      401 SRANDDBMSPIPERECEIVEMESSAGEGG 429 
WD40-rpts

7 WD40-repeats found in QUERY=2AQ5_A_PDBID_CHAIN_SEQUENCE (Len=429):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg  2    17-63       2.81  230.91  0.04707       17.5%     39.28
  WD 2:  Seg  6    64-110      7.99  444.69  6.3e-05       35.0%     51.07
  WD 3:  Seg 10   121-160      7.47  423.34  0.00012       40.0%     52.58
  WD 4:  Seg 14   164-204      7.74  434.56  8.7e-05       27.5%     57.52
  WD 5:  Seg 18   208-251      5.01  321.67  0.00288       25.0%     46.58
  WD 6:  Seg 22   252-296      5.53  343.20  0.00147       30.0%     45.70
  WD 7:  Seg 26   297-342      3.05  240.53  0.03513       10.0%     43.22

Multiple sequence alignment of 7 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1   17-63     QPA------KADQCYEDVRVS----QTTWDSGFCA--VNP-KFMA-L-ICEA---SG-GGAFLVLP
   WD 2   64-110    LGKTGRVDKNVPL------VC----GHTAPVLDIA--WCPHNDNV-I-A-SG---SE-DCTVMVWE
   WD 3  121-160    -RE------PVIT------LE----GHTKRVGIVA--WHP-TAQNVL-L-SA---GC-DNVILVWD
   WD 4  164-204    -GA------AVLT------LG--PDVHPDTIYSVD--WSR-DGAL-I-C-TS---CR-DKRVRVIE
   WD 5  208-251    -GT------VVAE------KD----RPHEGTRPVHAVFVS-EGKI-L-T-TGFSRMS-ERQVALWD
   WD 6  252-296    TKH------LEEP------LSLQELDTSSGVLLPF--FDP-DTNI-VYL-CG---KG-DSSIRYFE
   WD 7  297-342    ITS-EAPFLHYLS------MF----SSKESQRGMG--YMP-KRGL-E-V-NK---CEIARFYKLHE

   WD40 Template    TGE------CLRT------LS----GHTSGVTSVS--FSP-DGKR-L-V-SG---SE-DGTIKVWD